Registration Dossier
Registration Dossier
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EC number: 202-653-9 | CAS number: 98-29-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Little information is available about the test conditions and the results. No information about the test substance purity.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 952
- Report date:
- 1952
Materials and methods
- GLP compliance:
- no
- Test type:
- other: comparison of vapors evolved from the solid at room temperature and at 170°C
Test material
- Reference substance name:
- 4-tert-butylpyrocatechol
- EC Number:
- 202-653-9
- EC Name:
- 4-tert-butylpyrocatechol
- Cas Number:
- 98-29-3
- Molecular formula:
- C10H14O2
- IUPAC Name:
- 4-tert-butylbenzene-1,2-diol
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- other: no
- No. of animals per sex per dose:
- 6
Results and discussion
- Other findings:
- Six rats were exposed, in a 9 liter chamber, to air that had been passed at 2.5 liters per minute through a 100 ml burette loosely packed with 50 grams of p-t-butyl catechol and glass wool. None of the rats died as the result of an 8-hour exposure.
A mist, prepared by heating 50 grams of the compound to 170°C in a gas-washing bottle while air was passed through the fritted glass disc immersed therein, was lethal to 6 rats exposed for 1 hour while only 1 of 6 died in a similar 30-minute exposure. This compound is a solid at room temperature, but after heating at 170°C for 30 minutes it becomes and remains a viscous dark liquid at room temperature.
Applicant's summary and conclusion
- Conclusions:
- Vapors evolved at room temperature would not be hazardous but the vapor and aerosol produced by heating is definitely hazardous to life.
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