Registration Dossier

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Abstract information in OECD SIDS report of 2004; study described in OECD SIDS as valid without restrictions.

Data source

Reference
Reference Type:
secondary source
Title:
SIDS Initial Assessment Report For SIAM 19 - 3-Hydroxy-2-naphthoic acid
Author:
Anonymous
Year:
2004
Bibliographic source:
UNEP Publications

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
not specified
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3-hydroxy-2-naphthoic acid
EC Number:
202-180-8
EC Name:
3-hydroxy-2-naphthoic acid
Cas Number:
92-70-6
Molecular formula:
C11H8O3
IUPAC Name:
3-hydroxy-2-naphthoic acid

Test animals

Species:
rabbit

Test system

Type of coverage:
semiocclusive
Duration of treatment / exposure:
4h
Number of animals:
3

Results and discussion

In vivo

Results
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: no data
Score:
0.3
Reversibility:
fully reversible within: 48h
Remarks on result:
other: scores for both edema and erythema

Applicant's summary and conclusion