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EC number: 424-110-7 | CAS number: 194602-23-8 UK-143,108
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Conducted on 19 November 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: done under GLP and OECD method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EC Directive 88/302 'Biodegradation-Activated Sludge Respiration Inhibition test' and OECD guideline No.209'
- Principles of method if other than guideline:
- The study was conducted in accordance with OECD Guideline for Testing of Chemicals No. 209 and EEC Methods for the Determination of Ecotoxicity, EEC Directive 67/548 Annex VIII Part C (87/302/EEC), Activated Sludge, Respiratiqn Inhibition Test
Cultures of activated sewage sludge were incubated with synthetic sewage under vigorous aeration and in the presence of the test substance. Aeration was interrupted after 3 hours and the rates of respiration measured electrochemically for each culture. Percentage inhibition of respiration was calculated for each culture after a 3 hour contact period by comparing oxygen depletion rates for the test substance with those for the negative control culture - GLP compliance:
- yes
Test material
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Intended use: Pharmaceutical intermediate
Appearance: White powder
Storage conditions: In darkness at room temperature
Expiry: Not supplied
Purity: >97 %
Date received: 2 October 1996
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
REFERENCE SUBSTANCE
Identity
3,5-Dichlorophenol (C6H3Cl2.0H)
Aldrich Chemical Co Ltd, Batch no. 41205, Purity 97%.
The reference substance was dissolved in dilution water with the aid of ultrasonic disruption
Sampling and analysis
- Analytical monitoring:
- no
- Details on sampling:
- check if analytical sampling done to verify concnetration
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Test substance concentrations: 100mg/l in duplicate of test substance was dissolved directly in test water without the aid of auxiliary solvents or dispersing agents, with the aid of ultrasonic disruption
Reference substance: 3.2, 10 and 32 mg/l.
At time "O", 16 ml of synthetic sewage was made up to 300 ml with water in a 1 litre glass beaker. 200 ml of inoculum was added and the mixture aerated at approximately 0.5 - 1 litre per minute with compressed air via a narrow bore glass tube. This preparation was designated Control R1 Thereafter, at 15-minute intervals, further cultures were prepared following the same procedure but with the addition of appropriate amounts of test or reference substance to the vessels prior to adjusting the volume and adding the inoculum.
Test organisms
- Test organisms (species):
- sewage, domestic
- Details on inoculum:
- Type: A mixed population of activated sewage sludge micro-organisms.
Source: The aeration stage of the Anglian Water (Godmanchester) sewage treatment plant treating predominantly domestic sewage.
Preparation: A sample of activated sewage sludge was collected from the sewage treatment plant on 18 November 1996. The sample was maintained at 20°C with continuous aeration and used within 24 hours of collection. The pH was 7.9 and the suspended solids level of the sample was 7.2 g/l. Consequently, it was necessary to dilute the inoculum by a factor of two to obtain a suspended solid content of 3.6 g/l, to be within the 2 - 4 g/l range specified in the guidelines.
DILUTION WATER
Type
Laboratory tap water, dechlorinated by passage through activated carbon and softened by reverse osmosis (hardness approximately 120 - 180 mg/I as CaC03 , pH 7.5 ± 0.5).
Study design
- Test type:
- other: activated sewage sludge were incubated with synthetic sewage under vigorous aeration and in the presence of the test substance
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 3 h
- Post exposure observation period:
- As each culture reached 3 hours contact time its pH was recorded and the rate of respiration measured. A 280 ml darkened glass BOD bottle was completely filled with the culture and sealed by the Yellow Springs Dissolved Oxygen Meter (Model No. 57) dissolved oxygen probe whilst being stirred by a magnetic stirrer. The dissolved oxygen level was recorded for approximately 10 minutes (between approximately 6.5 and 2.5 mg02/l). Separate measuring bottles were used for control, test and reference cultures to eliminate the possibility of cross-contamination
Test conditions
- Hardness:
- No data
- Test temperature:
- 21 °C
- pH:
- no data in report but was recorded
- Dissolved oxygen:
- dissolved oxygen level was recorded for approximately 10 minutes (between approximately 6.5 and 2.5 mg02/l).
- Salinity:
- No Data
- Nominal and measured concentrations:
- UK-143,108:
3,5-dichlorophenol:
EC50 (3 hours):> 100 mg/I.
EC50 (3 hours):13 mg/l
- Details on test conditions:
- TEST SYSTEM: series
- Test vessel: 1 liter glass beaker
- Aeration: yes
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
test has test substance+synthetic sewage + inoculumn
controls has synthetic sewage + inoculumn only
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Laboratory tap water, dechlorinated by passage through activated carbon and softened by reverse osmosis (hardness approximately 120 - 180 mg/I as CaC03 , pH 7.5 ± 0.5).
TEST CONCENTRATIONS
- Test concentrations: Test substance: 100 mg/l in duplicate. Reference substance: 3.2, 10 and 32 mg/l. - Reference substance (positive control):
- yes
- Remarks:
- 3.5 dichlorophenyl
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0 - < 100 mg/L
- Remarks on result:
- other: UK-143,108
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- 13 mg/L
- Remarks on result:
- other: 3,5-dichlorophenol
- Details on results:
- Variation in respiration rates of Controls 1 and 2: ± 2 % .
- Results with reference substance (positive control):
- 3,5-dichlorophenol:EC50 (3 hours): 13 mg/I
- Reported statistics and error estimates:
- No Data
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- The validation criteria for (i) Control culture respiration and (ii) respiration inhibition by the reference substance, were fulfilled during this study
- Conclusions:
- The EC50 (respiration inhibition) value for UK-143, 108 with activated sewage sludge has been determined as > 100 mg/I for the 3 hour contact time.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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