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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2008-2010
Reliability:
1 (reliable without restriction)
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study
Qualifier:
according to
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
Version / remarks:
May 2008
Deviations:
no
Principles of method if other than guideline:
NA
GLP compliance:
no
Type of method:
determination of fibre length and diameter distributions
Type of distribution:
other: volumetric and counted distribution
Percentile:
D50
Mean:
>= 30 - <= 150 µm
Remarks on result:
other: overall range(migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.)
Size:
>= 5 - <= 400 µm
Remarks on result:
other: overall range for ca. 98 % or more of present particles

Fractions (%) <= 5 and/or 10 µm particle size (diameter) (overall values):

< = 5 µm: max. 5 %     < = 10 µm: max. 13 %

Conclusions:
The overall range of mass median diameter (D50) for dipotassium persulfate was determined at 30-150 µm. Particle size fractions < 100 µm, < 10 µm and < 5 µm were found. The overall range for ca. 98% or more of the present particles was 5-400 µm (aerodynamic diameter).
Executive summary:

All applied testing methods (counted and volumetric distribution) were performed in accordance with OECD guideline no. 110, Method A, 12 May 2008.

The overall range of mass median diameter (D50) for dipotassium persulfate was determined at 30-150 µm. Particle size fractions < 100 µm, < 10 µm and < 5 µm were found. The overall range for ca. 98% or more of the present particles was 5-400 µm (aerodynamic diameter).

Description of key information

The overall range of mass median diameter (D50) for dipotassium persulfate was determined at 30-150 µm. Particle size fractions < 100 µm, < 10 µm and < 5 µm were found. The overall range for ca. 98% or more of the present particles was 5-400 µm (aerodynamic diameter). All applied testing methods (counted and volumetric distribution) were performed in accordance with OECD guideline no. 110, Method A, 12 May 2008.

Additional information

According to the Technical Guidance document on Risk Assessment, particles with aerodynamic diameters < 100 µm have the potential to be inhaled. Particles with aerodynamic diameters of above 1-5 µm have the greatest probability of settling in the nasopharyngeal region whereas particles with aerodynamic diameters below 1-5 µm are most likely to settle in the tracheobronchial or pulmonary regions. For dipotassium persulfate particles up to < 5 µm were present. Max 18 % of particles were < 10 µm (total fraction).

Notably, the substance is classified and labelled as respiratory sensitizing category 1 (H 334: May cause allergy or asthma symptoms or breathing difficulties if inhaled) and specific target organ toxicity – single Category 3 (H335: May cause respiratory irritation) according to Regulation (EC) No 1272/2008.