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Diss Factsheets
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EC number: 214-604-9 | CAS number: 1163-19-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- genetic toxicity in vitro
- Remarks:
- Type of genotoxicity: other: gene mutation, chromosome aberration, sister chromatid exchange, mouse lymphoma
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986-1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Studies performed by the U.S. National Toxicology Program and/or experienced contract laboratories, and included in the EUR 20402 EN..
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 986
- Reference Type:
- publication
- Title:
- Responses of the L5178Y tk+/tk− mouse lymphoma cell forward mutation assay: III. 72 coded chemicals.
- Author:
- McGregor et al.
- Year:
- 1 988
- Bibliographic source:
- Environ Mol Mutagen 12:85–154. Erratum in: Environ Mol Mutagen (1988) 12:345.
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Reference Type:
- publication
- Title:
- Toxicology and human health assessment of decabromodiphenyl ether
- Author:
- Hardy et al.
- Year:
- 2 009
- Bibliographic source:
- Critical Reviews in Toxicology 39(S3):1-44
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 473 (In Vitro Mammalian Chromosome Aberration Test)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 479 (Genetic Toxicology: In Vitro Sister Chromatid Exchange Assay in Mammalian Cells)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Principles of method if other than guideline:
- see below.
- GLP compliance:
- yes
- Type of assay:
- other: see above
Test material
- Reference substance name:
- Bis(pentabromophenyl) ether
- EC Number:
- 214-604-9
- EC Name:
- Bis(pentabromophenyl) ether
- Cas Number:
- 1163-19-5
- Molecular formula:
- C12Br10O
- IUPAC Name:
- bis(pentabromophenyl) ether
Constituent 1
Method
- Target gene:
- see below
Species / strain
- Species / strain / cell type:
- other: see EURAR
- Details on mammalian cell type (if applicable):
- See EURAR
- Test concentrations with justification for top dose:
- See EURAR
- Vehicle / solvent:
- See EURAR
Controls
- Remarks:
- See EURAR
Results and discussion
Test results
- Species / strain:
- other: all tests
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity, but tested up to precipitating concentrations
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Test system |
Cell/strain; assay |
Result (+S9/-S9) |
Reference |
Bacteria |
|||
S. typhimurium |
TA98, 100, 1535, 1537; reverse mutation |
-/- |
Wagner and Kling (1998) (a) |
-/- |
NTP (1986) |
||
E. coli |
WP2 uvrA; reverse mutation |
-/- |
Wagner and Kling (1998) |
Mammalian cellsin vitro |
|||
Mouse lymphoma cells |
L5178Ytk+/tk-; forward mutation |
ND/- |
McGregor et al. (1988) |
Chinese hamster ovary cells |
Sister-chromatid exchange |
-/- |
NTP (1986) |
Chromosomal aberrations |
-/- |
NTP (1986) |
|
Mammalian cellsin vivo |
|||
Sprague Dawley rats |
Cytogenetic evaluation of bone marrow |
ND/- |
Norris et al. (1975) |
(a) Conducted in compliance with the US Food and Drug Administration’sGood Laboratory Practice for Nonclinical Laboratory Studies(FDA, 2002), the US EPA’sGood Laboratory Practice Standards(EPA, 1989, 1996), the United Kingdom’sGLP Compliance Programme, the Japanese GLP Standards, and the OECD’sPrinciples on Good Laboratory Practice(OECD, 1998).
ND = not determined.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
DecaBDE is not genetically active. - Executive summary:
No evidence of a genotoxic effect was detected in the Ames Salmonella, chromosome aberration, mouse lymphoma, or sister-chromatid exchange tests (McGregor et al., 1988; NTP, 1986; Wagner & Klug, 1998). No cytogenic changes were observed in the bone marrow of rats (parents and offspring) undergoing a one-generation reproduction test using FR-300-BA (Norris et al., 1975)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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