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Toxicological information

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Description of key information

Toxicity(Oral):LD 50 > 5000 mg/kg bw (OECD 401, GLP)

Toxicity(Dermal):LD 50 > 2000 mg/kg bw (OECD 402, GLP)

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Qualifier:
according to guideline
Guideline:
other: OECD 401 (1981)
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes
Species:
other: rat, Wistar
Vehicle:
other: 0,5 %ige wässrige Carboxymethylcellulose
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Mortality:
Male: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:
Keine Auffälligkeiten
«ENGLISCH+
No conspicuous findings
Gross pathology:
Effects on organs:
Keine Auffälligkeiten
«ENGLISCH+
No conspicuous findings
Interpretation of results:
other: not classified Migrated information Criteria used for interpretation of results: EU
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
5 000 mg/kg bw
Quality of whole database:
Data submitter has permission to refer Inquiry number 06-2120831335-60-0000

Acute toxicity: via inhalation route

Link to relevant study records
Reference
Endpoint:
acute toxicity: inhalation
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:
Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 000 mg/kg bw
Quality of whole database:
Data submitter has permission to refer Inquiry number 06-2120831335-60-0000

Additional information

Justification for classification or non-classification

The substance does not need to be classified for acute toxicity or specific target organ toxicity.

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