Tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate

Endpoint summary

Description of key information

Toxicity(Oral):LD 50 > 5000 mg/kg bw (OECD 401, GLP)

Toxicity(Dermal):LD 50 > 2000 mg/kg bw (OECD 402, GLP)

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Qualifier:

according to guideline

Guideline:

other: OECD 401 (1981)

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Species:

rat

Strain:

Wistar

Sex:

male/female

Route of administration:

oral: unspecified

Vehicle:

other: 0.5% aqueous carboxymethylcellulose

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Mortality:

Male : 5000mg/kg bw; number of animals : 5 ; number of deaths : 0
Female : 5000mg/kg bw; number of animals : 5 number of deaths : 0

Clinical signs:

other:

Gross pathology:

Effects on organs : No conspicuous findings

Interpretation of results:

other: not classified Migrated information Criteria used for interpretation of results: EU

Conclusions:

Not classified

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

> 5 000 mg/kg bw

Acute toxicity: via inhalation route

Link to relevant study records

Reference

Endpoint:

acute toxicity: inhalation

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Link to relevant study records

Reference

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Qualifier:

according to guideline

Guideline:

other: OECD 402 (1981)

GLP compliance:

yes

Limit test:

yes

Species:

rat

Strain:

other: common species

Sex:

male/female

Type of coverage:

semiocclusive

Vehicle:

olive oil

Duration of exposure:

24 h

Control animals:

not specified

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Mortality:

Male : 2000 mg/kg bw ; number of animals : 5 ; number of deaths : 0
Female : 2000 mg/kg bw ; number of animals : 5 ; number of deaths : 0

Clinical signs:

other:

Gross pathology:

Effects on organs : No conspicuous findings

Other findings:

Signs of toxicity (local) : No conspicuous findings

Interpretation of results:

other: not classified Migrated information Criteria used for interpretation of results: EU

Conclusions:

not classified

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

> 2 000 mg/kg bw