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Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
sub-chronic toxicity: oral
Remarks:
other: not specified
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: only summary available

Data source

Reference
Reference Type:
other: ECHA summary
Title:
Unnamed
Year:
2010

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)
GLP compliance:
yes
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate
EC Number:
402-070-1
EC Name:
Tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate
Cas Number:
88122-99-0
Molecular formula:
C48H66N6O6
IUPAC Name:
2-ethylhexyl 4-({4,6-bis[(4-{[(2-ethylhexyl)oxy]carbonyl}phenyl)amino]-1,3,5-triazin-2-yl}amino)benzoate

Test animals

Species:
rat
Strain:
Wistar

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
unchanged (no vehicle)
Duration of treatment / exposure:
Test Duration: 90 days
Frequency of treatment:
Dosing regime: 7 days/week

Results and discussion

Results of examinations

Details on results:
Clinical observations:
No premature mortalities occurred
Clinically, Laboratory-diagnostically and pathomorphologically, no substance-related pathological changes could be observed

Laboratory findings:
Slight variations in the haematological and clinico-chemical paramters corresponded to the range of biological variation in the specieis.

Effects in organs:

Liver-weight increases without histological correlates among treated female animals could not be interpreted as being substance-related.

Effect levels

Dose descriptor:
NOEL
Effect level:
1 000 mg/kg bw/day (nominal)
Basis for effect level:
other: Original NCD unit is mg/kg/day

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Not classified

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