Registration Dossier
Registration Dossier
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EC number: 402-070-1 | CAS number: 88122-99-0 UVINUL T 150
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Remarks:
- other: not specified
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: only summary available
Data source
Reference
- Reference Type:
- other: ECHA summary
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- Tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate
- EC Number:
- 402-070-1
- EC Name:
- Tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate
- Cas Number:
- 88122-99-0
- Molecular formula:
- C48H66N6O6
- IUPAC Name:
- 2-ethylhexyl 4-({4,6-bis[(4-{[(2-ethylhexyl)oxy]carbonyl}phenyl)amino]-1,3,5-triazin-2-yl}amino)benzoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- Test Duration: 90 days
- Frequency of treatment:
- Dosing regime: 7 days/week
Results and discussion
Results of examinations
- Details on results:
- Clinical observations:
No premature mortalities occurred
Clinically, Laboratory-diagnostically and pathomorphologically, no substance-related pathological changes could be observed
Laboratory findings:
Slight variations in the haematological and clinico-chemical paramters corresponded to the range of biological variation in the specieis.
Effects in organs:
Liver-weight increases without histological correlates among treated female animals could not be interpreted as being substance-related.
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- 1 000 mg/kg bw/day (nominal)
- Basis for effect level:
- other: Original NCD unit is mg/kg/day
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Not classified
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