Cinnamaldehyde

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard OECD test guidelines

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

GLP compliance:

no

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Type:

log Pow

Partition coefficient:

2.107

Temp.:

25 °C

Remarks on result:

other: pH not available

The Log Pow of test chemical was determined to be 2.1065±0.001 7at 25°C.

Reference substance	Log Pow	tR1	tR2	tR3	MeantR± S.D.	k	Log k
Formamide	-	0.977	0.922	0.922	0.9403±0.0317	-	-
4 Acetyl Pyridine	0.5	1.076	1.077	-	1.076±0.0007	0.144	-0.839
Cinnamyl Alcohol	1.9	1.219	1.221	-	1.22±0.0014	0.2974	-0.526
Toluene	2.7	2.103	2.104	-	2.1025±0.0007	1.237	-0.092
Naphthalene	3.6	2.388	2.393	-	2.390±0.0035	1.542	0.188
Biphenyl	4	2.822	2.841	-	2.831±0.028	2.011	0.303
N butyl benzene	4.6	4.454	4.463		4.458±0.0063	3.741	0.572

 

Test substance		k	Log k	Log Pow by Calibration Graph	Mean of Log Pow± S.D.
tR1	1.393	0.4814	-0.3174	2.105	2.1065±0.0017
tR2	1.394	0.4825	-0.3165	2.108

Conclusions:

The partition coefficient of test substance was determined as per the HPLC method (OECD Guideline-117). The Log Pow value was determined to be 2.1065± 0.0017at 25°C.

Executive summary:

The partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for Testing of Chemicals. The reference substances were chosen according to structural similarity with the test substance. The reference substances were 4 Acetyl Pyridine, Cinnamyl alcohol, Toluene, Naphthalene, Biphenyl, n – Butyl alcohol having Pow value ranging from 0.5 to 4.6. TheLog Powvalue was determined to be 2.1065±0.0017at 25°C.

By considering this log Pow value it can be concluded that test chemical is hydrophilic in nature.

Description of key information

On the basis of available data from study report, the partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for Testing of Chemicals. The reference substances were chosen according to structural similarity with the test substance. The reference substances were 4 Acetyl Pyridine, Cinnamyl alcohol, Toluene, Naphthalene, Biphenyl, n – Butyl alcohol having Pow value ranging from 0.5 to 4.6. The log Pow value was determined to be 2.1065±0.0017at 25°C.

Key value for chemical safety assessment

Log Kow (Log Pow):

2.1

at the temperature of:

25 °C

Additional information

On the basis of available data from study report, the partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for Testing of Chemicals. The reference substances were chosen according to structural similarity with the test substance. The reference substances were 4 Acetyl Pyridine, Cinnamyl alcohol, Toluene, Naphthalene, Biphenyl, n – Butyl alcohol having Pow value ranging from 0.5 to 4.6. The log Pow value was determined to be 2.1065±0.0017at 25°C.

Additional study from handbooks indicates the octanol water partition co-efficient (log Pow) of test chemical was determined to be 1.88 at 25°C.

Thus, based on the available information, test chemical was considered tobehydrophilic in nature.