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Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
multi-generation reproductive toxicity
Remarks:
based on test type (migrated information)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
other: Authoritative data base
Title:
HSDB Number 209
Year:
2011
Bibliographic source:
HSDB (Hazardous Substances Data Bank); US national Library of Medicine reviewed by SRC
Reference Type:
other: Authoritative data base
Title:
No information
Year:
2012
Bibliographic source:
NTP (National Toxicological Program)by Agency for Toxic Substances and Disease Registry; Division of Toxicology/Toxicology Information Branch, 1600 Clifton Road NE, E-29, Atlanta, Georgia 30333
Reference Type:
other: Authoritative data base
Title:
No information
Year:
2011
Bibliographic source:
ACToR(Aggregated Computational Toxicology Resource)Mantovani, A.,Stazi, A.V.,Macri,C.,Ricciardi,C.,Piccioni,A.andBadellino,W.(1989).Pre-Natal(Segment II) Tox.Study of Cinnamic Aldehyde in the Sprague-Dawley Rats.Food and Chemical Toxico.27(12): 781-786.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Cinnamic aldehyde was administered by gavage to Sprague-Dawley rats on days 7-17 of pregnancy at doses of 5, 25 or 250 mg/kg/day.Test Type: Pre-Natal (Segment II) Toxicity Study.Duration of test: Days 7-17 of pregnancy
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Cinnamaldehyde
EC Number:
203-213-9
EC Name:
Cinnamaldehyde
Cas Number:
104-55-2
Molecular formula:
C9H8O
IUPAC Name:
3-phenylacrylaldehyde
Test material form:
liquid: viscous
Details on test material:
- Name of test material (as cited in study report): cinnamaldehyde
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Type of inhalation exposure (if applicable):
not specified
Vehicle:
olive oil
Doses / concentrations
Remarks:
Doses / Concentrations:
5, 25 or 250 mg/kg/day
Basis:
no data

Examinations

Parental animals: Observations and examinations:
No signs of maternal toxicity observed
Statistics:
Statistical evaluations: Kruskal-Wallis test, Mann-Wittney test

Results and discussion

Results: P0 (first parental generation)

Details on results (P0)

No signs of maternal toxicity, decreased weight gain between day 7 & 20 with decrease in food intake.

Results: F1 generation

Details on results (F1)

Offspring toxicity F1 and F2: Increased incidence of poor cranial ossification, decreased ossification of tympanic bulla at 25 or 250 mg/kg/day, increased incidence of dilated pelvis/reduced papilla in kidney, increased incidence of reduced cranial ossification, dilated ureter.

Results: F2 generation

Effect levels (F2)

Dose descriptor:
LOAEL
Generation:
F2
Effect level:
5 mg/kg bw/day
Based on:
test mat.
Sex:
female

Overall reproductive toxicity

Reproductive effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Administration of Cinnamaldehyde to pregnant rats resulted in increased incidence of poor cranial ossification and reduced ossification of the tympanic bulla. Significant increases of the incidences of dilated pelvis/reduced papilla in the kidney, ureters > 2 abnormal sternebrae per fetus were also reported.
Executive summary:

Cinnamaldehyde was administered by gavage to Sprague-Dawley rats on days 7-17 of pregnancy at doses of 5, 25 or 250 mg/kg/day. Test carried out for duration 7-17 days of pregnancy. Offspring toxicity F1 and F2 showed increased incidence of poor cranial ossification, decreased ossification of tympanic bulla at 25 or 250 mg/kg/day, increased incidence of dilated pelvis/reduced papilla in kidney, increased incidence of reduced cranial ossification, dilated ureter. However,No signs of maternal toxicity observed. The lowest observed adverse effect level (LOAEL) found to be 5 mg/kg bw/day