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EC number: 205-594-7 | CAS number: 143-24-8
Analogue approach justification (target chemical: tetraglyme; source chemicals: di- and monoglyme)
The target and the source chemical belong to the homologues series of glymes, where there is an incremental increase in the number of CH2CH2O units. The dermal penetration property of the target chemical is expected to be comparable to those of the proposed source chemicals, because the relevant physico-data (water solubility, LogPow) on target and source chemicals do not deviate significantly from each other. The molecular size of target chemical, althogh significantly higher than those of source chemicals, is still in the range indicative of higher skin penetration and is not likely to influence the skin penetration property significantly.
Tetraglyme is expected to be readily bioavailable upon dermal application based on the read-across appraoch using di- and monoglyme as source chemicals.
An in vitro skin absorption study was performed applying diglyme to dermatomed human skin.
For diglyme, the lag time was reported to be 36 +/- 3 min and the flux at steady state permeation was 0.952 +/- 0.340 mg/cm2/h.
For monoglyme, the lag time was reported to be 39 +/- 3 min and the flux at steady state permeation was 3.434 +/- 1.897 mg/cm2/h.
Based on the obtained results, it can be concluded that diglyme and monoglyme are dermally readily bioavailable.
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