Registration Dossier
Registration Dossier
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EC number: 218-645-3 | CAS number: 2210-79-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Under the conditions of this study, the administration of 2, 3-epoxypropyl o-tolyl ether (EPOTE) at actual dose levels up to and including 500 mg/kg/day was evaluated as negative for the induction of cII mutants in liver and testes of Big Blue® mice.
Short description of key information:
The test substance, 2,3-epoxypropyl o-tolyl ether was accessed for
in vitro genotoxicity in two independent Ames/Salmonella mutation tests
and an in vitro huiman lymphocyte DNA repair UDS study. Potential in
vivo genotoxicity was evaluated in two mouse micronucleus (chromosome
damage) studies, a male mouse dominate lethal assay and 2 MutaMouse
gene-mutation assay in bone marrow, liver, skin or liver and testes.
Endpoint Conclusion: Adverse effect observed (negative)
Justification for classification or non-classification
The weight-of-evidence demonstrates that there is insufficient in vivo genotoxicity evidence to Classify and Label the test substance as a Mutagen.
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