Registration Dossier
Registration Dossier
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EC number: 234-685-4 | CAS number: 12023-91-5
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- sub-chronic toxicity: dermal
- Data waiving:
- exposure considerations
- Justification for data waiving:
- a short-term toxicity study does not need to be conducted because exposure of humans via the dermal route in production and/or use is not likely as based on the provided thorough and rigorous exposure assessment
- Justification for type of information:
- The likely route of human exposure is inhalation. According to Annex VIII 8.6.1 column 1 the likely route of human exposure must be regarded for a short-term repeated dose toxicity study (28 days). The likely route of human exposure is inhalation. Thus a short-term repeated dose toxicity study (28 days) for the dermal route is not required. According to Annex IX 8.6.2 column 1 the likely route of human exposure must be regarded for a sub-chronic (90 days) toxicity study. The likely route of human exposure is inhalation. Thus a sub-chronic toxicity study (90 days) for the dermal route is not required. A long-term repeated toxicity study (>/= 12 months) is not proposed as none of the conditions of Annex X 8.6.3. column 2 are met.
Data source
Materials and methods
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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