Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

Three studies were performed to examine potential genetic toxicity of strontium ferrite:

  1. Ames-test according to OECD Guideline 471 (Bacterial Reverse Mutation Assay)
  2. in-vitro gene mutation study according to OECD Guideline 476 (In vitro Mammalian Cell Gene Mutation Test)
  3. in-vitro cytogenicity study according to OECD Guideline 473 (In vitro Mammalian Chromosome Aberration Test)

Strontium ferrite showed to be not mutagenic in the Ames-test bacterial test systems either with or without exogenous metabolic activation at the dose levels investigated. Strontium ferrite is also not genotoxic in the mammalian cells test system according to OECD 476 (mouse lymphoma assay) either with or without exogenous metabolic activation at the dose levels investigated. Too, strontium ferrite is not cytotoxic - does not produce chromosome aberration - in the mammalian cells test system according to OECD 473 (chromosome aberration test) either with or without exogenous metabolic activation at the dose levels investigated.

A study on in-vivo genetic toxicity is not required due to Annexes IX and X REACH as strontium ferrite did not show a positive result in any of the in-vitro genotoxicity studies performed as to annexes VII and VIII.

Strontium ferrite is not considered as a mutagen.


Short description of key information:
Strontium ferrite is not mutagenic in the Ames-test bacterial test systems either with or without exogenous metabolic activation at the dose levels investigated. Strontium ferrite is also not genotoxic in the mammalian cells test system according to OECD 476 (mouse lymphoma assay) either with or without exogenous metabolic activation at the dose levels investigated. Too, strontium ferrite is not cytotoxic - does not produce chromosome aberration - in the mammalian cells test system according to OECD 473 (chromosome aberration test) either with or without exogenous metabolic activationat the dose levels investigated

Strontium ferrite is not considered as a mutagen.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Strontium ferrite does not show mutagenic properties (genetic toxicity). Thus classification is not required.