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Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: results presented as graphics only

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984
Report date:
1984

Materials and methods

Principles of method if other than guideline:
hydrazin solutions in various aqueous concentrations were applied to the skin of rabbits over selected time periods and serum hydrazin concentrations were determined
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Hydrazine
EC Number:
206-114-9
EC Name:
Hydrazine
Cas Number:
302-01-2
Molecular formula:
H4N2
IUPAC Name:
hydrazine
Details on test material:
anhydrous hydrazine, hydrazine 70 %,, hydrazine 15 % and 2 % hydrazine solution
Radiolabelling:
not specified

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
other: no vehicle or water
Duration of exposure:
up to 12 minutes
Doses:
Anhydrous hydrazine, hydrazine 70 %,, hydrazine 15 % and 2 % hydrazine solution.
No. of animals per group:
no data

Results and discussion

Signs and symptoms of toxicity:
not specified
Dermal irritation:
yes
Absorption in different matrices:
for available information see section remarks on results
Total recovery:
for available information see section remarks on results

Any other information on results incl. tables

RM-Freetext: (graphics only)
Result: time-limitation of percutaneous Hz exposure (2, 6, 12 minutes) demonstrated a direct correlation between duration of exposure and peak serum. Hydrazine concentrations for both Hz and Hz70%. A correlation of time to peak serum Hz level with duration of Hz exposure was also evident with anhydrous Hz but not Hz70%. Serun Hz levels peaked at 50 -90 min for anhydrous Hz and at 30 -50 min for Hz70%. Total percutaneous Hz absorption from anhydrous Hz or Hz70% was also directly related to duration of Hz exposure. In addition the rate of Hz absorption was greater for anhydrous Hz than for Hz70% . The peak serum Hz concentration was greater for Hz15% than for Hz2%. These peak serum Hz concentration occurred at 30 min for Hz15% and at 10 min for Hz2%. There was an increase in the percent Hz dose absorbed as the Hz solution concentration increased. tissue evaluation: severe chemical burns were found in rabbits percutaneously exposed to annydrous Hz or Hz70%. These lesions typically contained areas of transepidermal necrosis with varying degrees of dermal necrosis. No significant lesions were noter following percutaneous exposure to Hz15% or Hz2%.

Applicant's summary and conclusion

Executive summary:

Hydrazin is absorbed through the skin of rabbits (Keller 1984).