Registration Dossier
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EC number: 235-123-0 | CAS number: 12070-12-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998-02-24 to 1999-06-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Well documented, scientifically sound study that followed OECD Guideline 401 and GLP.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
- Reference Type:
- publication
- Title:
- SIDS Initial Assessment Report for SIAM 21 for Tungsten Carbide (12070-12-1), Washington DC,18-20 October, 2005
- Author:
- OECD-SIDS
- Year:
- 2 005
- Bibliographic source:
- UNEP Publications
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- The lowest humidity recorded was 29%. This was lower than the range of 30 - 70% stated in the protocol. This deviation was not considered to have affected the integrity or validity of the study.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Test substance: tungsten carbide, WC HC 240
- Purity: 99.98%
- Physical state: Grey powder
- Storage condition of test material: Room temperature
- Expiration date of the lot/batch: Not advised
Test animals
- Species:
- rat
- Strain:
- other: Hsd: Sprague-Dawley(CD))
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Obtained from Harlan U.K. Ltd, Bicester, Oxon, England.
- Age at study initiation: four to seven weeks or age.
- Weight at study initiation: range of 80 to 101 g.
- Fasting period before study: Access to food only was prevented overnight prior to and for approximately 4 hours after dosing.
- Housing: Rats were allocated without conscious bias to cages within the treatment group and housed in groups of five rats of the same sex in metal cages with wire mesh floors.
- Diet (e.g. ad libitum): A standard laboratory rodent diet (Special Diet Services RM1(E) SQC expanded pellet)
- Water: drinking water provided ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 21 to 22.5 degree C
- Humidity: 9-52%
- Air changes: Air exchange was maintained at 10 to 15 air changes per hour.
- Photoperiod: lighting controlled by means of a time switch to provide 12 hours of artificial light (0700 - 1900 hours).
IN-LIFE DATES: From: 1998-02-24 To: 1998-03-10
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 1 % w/v aqueous methylcellulose
- Details on oral exposure:
- The test substance was formulated at a concentration of 20 % (w/v) in 1 % (w/v) aqueous methylcellulos which was administered at a volume of 10 mL/kg-bw.
- Doses:
- single oral gavage dose of 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 male and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- no data
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- other: NOEL
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- 0/5 for males and females
- Clinical signs:
- Piloerection was observed in all rats within three minutes of dosing. This sign persisted and was accompanied on Day 2 only by ungroomed appearance (characterised by ungroomed coat) in all males. There were no other signs of reaction to treatment and recovery was complete in all animals by Day 3.
- Body weight:
- No changes in body weight gain were seen.
- Gross pathology:
- No macroscopic abnormalities at terminal kill on day 15 were observed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute lethal oral dose to rats of Tungsten Carbide Powder - Pure was demonstrated to be greater than 2000 mg/kg bodyweight.
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