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Long-term toxicity to aquatic invertebrates

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One reliable (Klimisch 1, guideline- and GLP-compliant) study addresses the long-term toxicity of terephthalic acid to freshwater invertebrates.   
In this study (Government of Japan, Ministry of the Environment, 2003c), Daphnia magna were exposed to high purity TPA (free acid), dosed from a stock solution prepared with DMSO, at a concentration intended to approximate to TPA's aqueous solubility limit. No toxicity was observed under these test conditions:
D. magna 21 -d NOEC (semi-static): 19.5 mg TPA/L.
This endpoint is a mean measured value and represents the maximum limit concentration achievable under the test conditions.
Terephthalic acid exhibits low long-term toxicity to aquatic invertebrates.

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