Registration Dossier
Registration Dossier
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EC number: 201-161-1 | CAS number: 78-95-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1986
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Hazard evaluation of monochloroacetone
- Author:
- E.V. Sargent
- Year:
- 1 986
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J 47(7); 375
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Chloroacetone
- EC Number:
- 201-161-1
- EC Name:
- Chloroacetone
- Cas Number:
- 78-95-5
- Molecular formula:
- C3H5ClO
- IUPAC Name:
- 1-chloropropan-2-one
- Details on test material:
- purtiy: approx. 93%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- 9 weeks old
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The test compound was held in contact with imperivious platic sheeting. Collars, desinged to prevent licking, were placed on the necks of the animals.
- Duration of exposure:
- 24 hours
- Doses:
- 50, 100, 200 and 400 mg/kg
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 141 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- The dermal LD 50 was determined by Sargent et al to be 141 mg/kg.
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