Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 201-161-1 | CAS number: 78-95-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
From the "BUA Stoffbericht"
Monochloroacetone is a potent tear gas. In humans, monochloroacetone causes irritation of the eyes and upper respiratory tract. Skin contact causes painful blistering. In animal experiments, lung edema and hydrothorax were observed after inhalation exposure.
From HSDB database:
Animal data:
Chlroacetone gives off heavy vapors ... it causes much lacrimation @ concn of 5 to 8 ppm in air, & @ higher concn causes clouding of cornea which has not been described in detail. concn of 26 ppm in air is intolerable for more than a min because of severe irritation of all mucous membranes.
[grant, w.m. toxicology of the eye. 3rd ed., il: charles c. thomas publisher, 1986., p. 207] **peer reviewed**
dermal application of chloracetone to stock mice in 183 days had no tumorigenic effects, but 24 applications to albino mice, 0.2 ml, 0.3% in acetone (promotion with croton oil, 0.2 ml, 0.3% in acetone, 20 wk), in 365 days resulted in 44/19 papillomas, 10/20 papillomas in controls. /from table/
[searle, c. e. (ed.). chemical carcinogens. acs monograph 173., dc: american chemical society, 1976., p. 160] **peer reviewed**
Human experience:
the vapor of this liquid is a strong lacrimator & is irritating to skin & respiratory tract. concn of 0.018 mg/l is sufficient to produce lacrimation & concn of 0.11 mg/l will normally not be tolerated for more than 1 min.[international labour office. encyclopedia of occupational health and safety. vols. i&ii.,: international labour office, 1983., p. 39] **peer reviewed**
... chloroacetone was extremely effective as a war gas. ... a concn of 2.3 mg/l (605 ppm) was found to be lethal after 10 min and 0.1 mg/l (26 ppm) is intolerable after one min of exposure. ... the effect ... is ... irritation of the upper resp tract and a burning sensation on exposed skin. ... most serious effects, such as pulmonary edema, do not occur at these low irritating concn. even small amt in the eyes may result in permanent damage.
[american conference of governmental industrial hygienists, inc. documentation of the threshold limit values and biological exposure indices. 6th ed. volumes i, ii, iii. cincinnati, oh: acgih, 1991., p. 262] **peer reviewed**
an employee that received direct exposure to hot chloroacetone required hospitalization; the fumes were immediately irritating to the eyes and upper resp tract, and the hot liq was immediately irritating to the skin. the immediate erythema appeared to subside; however, about 8 hr after exposure, the exposed areas began to blister, and 24 hr post exposure the exposed area had blistered completely. all signs and symptoms disappeared within 7 days, and there was no evidence of pulmonary edema despite irritation to the upper resp tract.
[american conference of governmental industrial hygienists, inc. documentation of the threshold limit values and biological exposure indices. 6th ed. volumes i, ii, iii., oh: acgih, 1991., p. 262] **peer reviewed**
human experience with chloroacetone is limited ... because of the highly irritating nature of the chemical.
[american conference of governmental industrial hygienists, inc. documentation of the threshold limit values and biological exposure indices. 6th ed. volumes i, ii, iii., oh: acgih, 1991., p. 262] **peer reviewed**
... the first experienced effect is lacrimation ... followed by irritation of the upper respiratory tract and a burning sensation on exposed skin. ... even small amounts in the eyes may result in permanent damage.
[american conference of governmental industrial hygienists, inc. documentation of the threshold limit values and biological exposure indices. 6th ed. volumes i, ii, iii., oh: acgih, 1991., p. 262] **peer reviewed**
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: irritating
Effects on respiratory irritation: irritating
Justification for classification or non-classification
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