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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Carcinogenicity

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Administrative data

Description of key information

The available data and available weight of evidence demonstrate that Hydrocarbons, C9 -C10, n-alkanes, isoalkanes, cyclics, <2% aromatics is highly unlikely to be carcinogenic and is not classifiable as a carcinogen.  

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no study available

Carcinogenicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Carcinogenicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Hydrocarbons, C9-C10, n-alkanes, isoalkanes, cyclics, <2% aromatics does not meet the criteria for classification as a carcinogen under the Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).

Additional information

The available read across data demonstrate that Hydrocarbons, C9-C10, n-alkanes, isoalkanes, cyclics, <2% aromatics is highly unlikely to be carcinogenic and is not classifiable as a carcinogen. Further testing is not required under Annex XI, section 1.2.

 

No standard carcinogenicity studies are available for Hydrocarbons, C9-C10, n-alkanes, isoalkanes, cyclics, <2% aromatics. However, with regard to the molecular structure of the substance, no carcinogenic potential is expected. Moreover, in investigations on read across mutagenicity (in vitro and in vivo) as well as in read across repeated dose toxicity studies (oral route and via inhalation), neither genotoxicity nor an indication for neoplastic lesions was observed.

Skin tumor promotion - Evidence of increased tumor promotion was observed in the tests of normal paraffins. The tumor promotion activity was greatest in the treated groups displaying the highest degree of dermal irritation, i.e. 100% v/v normal paraffin test material. A low tumor incidence occurred in the groups receiving 50% or 28.6% /v normal paraffin test material (not statistically different from the control group), which correlated to low degrees of dermal irritation. The skin tumor promoting properties of these substances are considered related to repeated dermal irritation (Nessel, 1999).

 

Nessel, Craig S., James J. Freeman, Richard C. Forgash, and Richard H. McKee. 1999. The Role of Dermal Irritation in the Skin Tumor Promoting Activity of Petroleum Middle Distillates. Toxicological Sciences 49, 48-55 (1999).