Registration Dossier
Registration Dossier
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EC number: 203-919-7 | CAS number: 111-90-0
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Life-threatening triclopyr poisoning due to diethylene glycol monoethyl ether solvent
- Author:
- Isoardi KZ, Page CB, Roberts MS, Isbister GK
- Year:
- 2 020
- Bibliographic source:
- Clin Toxicol. doi: 10.1080/15563650.2020.1757103.
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- acute toxicity: oral
- Principles of method if other than guideline:
- Case history of poisoning incident
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-(2-ethoxyethoxy)ethanol
- EC Number:
- 203-919-7
- EC Name:
- 2-(2-ethoxyethoxy)ethanol
- Cas Number:
- 111-90-0
- Molecular formula:
- C6H14O3
- IUPAC Name:
- 2-(2-ethoxyethoxy)ethan-1-ol
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Solvent for a low toxicity herbicide Triclopyr with latter at concentration of 50g/L
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: 1
- Sex: Male
- Age: 79
- Known diseases: Hypertension and atrial fibrillation - Ethical approval:
- not applicable
- Route of exposure:
- oral
- Reason of exposure:
- intentional
- Exposure assessment:
- estimated
- Details on exposure:
- Patient had consumed a 250mL bottle of the mixture, ie approximately 235g 2-(2-ethoxyethoxy)ethanol
- Examinations:
- Serum 2-(2-ethoxyethoxy)ethanol, lactate, anion gap, pH plus normal vital signs.
- Medical treatment:
- Intubation and ventilation, 100mmol of 8.4% bicarbonate to treat metabolic acidosis followed by sustained low-efficiency dialysis at 10h post ingestion for 10h. Recovered and discharged after 33 days.
Results and discussion
- Clinical signs:
- Glasgow coma scale on admission 11 (motor [M]6). Admission complicated by delerium and aspiration pneumonia. Central nervous system depression, a raised osmolar gap and a high anion gap metabolic acidosis that was cleared with dialysis. Type two respiratory failure compounded the acidaemia.
- Results of examinations:
- Serum pH rose to ~7.4 20 hours post presentation and anion gap fell to ~8mmol/L. 2 hours post presentation 2-(2-ethoxyethoxy)ethanol serum level was ~2200mg/L falling to zero within 15 hours
- Outcome of incidence:
- Intensive care resulted in survival of patient.
Applicant's summary and conclusion
- Executive summary:
In a case of deliberate ingestion by a 79 year old male of a large quantity of 2 -(2 -ethoxyethoxy)ethanol resulting in an estimated dose in excess of 3g/kg, following intensive hospital treatment, the patient survived. The main cause of toxicity of 2 -(2 -ethoxyethoxy)ethanol is acidosis caused by rapid metabolism to 2 -(2 -ethoxyethoxy)acetic acid.
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