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Long-term toxicity to aquatic invertebrates

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Description of key information

No effects up to the limit of water solubility for Daphnia magna (OECD 202 part 2)

Key value for chemical safety assessment

Additional information

There are no studies on aquatic invertebrate toxicity available for 2-ethylhexyl laurate (CAS No. 20292-08-4). The assessment of long-term toxicity was therefore based on studies conducted with the structurally most similar category member, for which data is available, isopropyl myristate (CAS No. 110-27-0), as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 6.1 and within the category justification Section 13.

The key study with isopropyl myristate (CAS No. 110-27-0) was performed according to the OECD guideline 202 part 2 (similar to OECD 211) and GLP (Wierich, 1995). The test organism Daphnia magna was exposed to the test substance in a semi-static system for 21 days, at nominal test concentrations of 0, 1 and 100 mg/L. The substance did not have any effect on the reproduction of Daphnia magna at the tested concentrations. A NOEC of ≥ 100 mg/L is reported.

Thus, based on theabove mentioned result, and due to the structural and profile similarities of the two substances, as are explained with in the overall endpoint summary 6.1 it can be concluded that no toxicological long-term effects on aquatic invertebrates are expected up tothe limit ofwater solubility for 2-ethylhexyl laurate (CAS No. 20292-08-4).