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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
toxicity to reproduction
Remarks:
other: 90-d repeated dose study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data are given

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1983

Materials and methods

Principles of method if other than guideline:
Performed according to the NTP protocol
GLP compliance:
not specified

Test material

Constituent 1
Details on test material:
- CAS number (as cited in study report): 1854-26-8
- Substance type: aqueous solution
- Physical state: liquid
- Purity: 41.4%
- Stability One lab stated that the test solutions would be stable for 2 weeks when stored in the dark at room temperature.
- Impurities (identity and concentrations): 0.8% formaldehyde

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Duration of treatment / exposure:
Exposure period: 90 d
Frequency of treatment:
5x/wk.

Results and discussion

Overall reproductive toxicity

Reproductive effects observed:
not specified

Any other information on results incl. tables

Microscopic inspection of sex organs (including testis, epididymis, prostate, preputial gland/uterus, ovaries, clitoral gland) gave no indication to morphological abnormalities. No histopathological changes up to 3000 mg/kg/d in male rats and up to 6000 mg/kg/d (referring to 100 % substance) in female rats.

Applicant's summary and conclusion