Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

4h-LC50 = 164000 ppm (309018 mg/m3); 4 -h LOAEL = 84000 ppm (158277 mg/m3)

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
309 018 mg/m³ air
Physical form:
inhalation: gas
Quality of whole database:
Available data show consistent results; conclusions fulfil the quality criteria (validity, reliability, repeatability).

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Predominant acute effect of inhalational exposure to high concentrations of DME is anaesthesia. Narcotic effects have been reported in humans at an atmospheric concentration of 120000 ppm.

The substance has low inhalation toxicity (lethality) with a rat 4-hour LC50 value of 164000 ppm. During inhalation to concentrations of 84000 ppm acute toxicity was observed in the form of ataxia, anaesthesia in 2 hours, short jerky respirations and lung noise (post exposure).During inhalation to ≥ 121000 ppm acute toxicity was observed in the form of ataxia, anaesthesia in 15 -30 minutes, heavy respiration, coma and lung noise (post exposure).


This substance is a gas, and tests to evaluate dermal and oral systemic toxicity are technically not feasible.

Justification for classification or non-classification

Based on the rat 4-hour LC50 of 164000 ppm (309018 mg/m3), anesthetic and clinical effects after 2 hours of exposure to 84000 ppm (158277 mg/m3), and the minimal startle response effects at 20000 ppm (37685 mg/m3) in the developmental study, the substance does not need to be classified for acute toxicity according the EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.