3-chloropropyltrimethoxysilane

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1993

Report date:

1993

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: micronucleus test

GLP compliance:

yes

Limit test:

no

Test material

Test material information

Constituent 1

Test animals

Species:

mouse

Strain:

Swiss Webster

Sex:

male/female

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

unchanged (no vehicle)

Doses:

0 (corn oil), 500, 1000 or 1625 mg/kg

Details on study design:

Chloropropyltrimethoxysilane (CAS No. 2530-87-2) was given to both male and female Swiss-Webster mice as a single dose by intraperitoneal injection. Exposure time = 30, 48 and 72 hours

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

other: micronucleus test

Effect level:

2 031 mg/kg bw

Clinical signs:

There were no signs of toxicity in male or female mice in the 500 mg/kg  group, except that 1 female exhibited ataxia during the first hour post-treatment. All of the males and females in the 1000 mg/kg group exhibited ataxia and 2 of the males also had tremors 
during the first  hour after treatment.  In males and females treated at 1625 mg/kg CPTMO,  ataxia, tremors, and prostration were 
observed during the first hour after treatment.  Other clinical signs in the high dose females included  myoclonic jerks and vocalization.  
There were no significant clinical  observations in male or female mice from the afternoon of Day 1 through  the end of the study.

Any other information on results incl. tables

Based upon mortality data obtained in a range-finding study, the acute intraperitoneal LD50 for the combined sexes was calculated to be 2031 mg/kg chloropropyltrimethoxysilane (95% confidence interval, 1672 to 2456 mg/kg).

Applicant's summary and conclusion

Conclusions:

In a micronucleus study, no signs of toxicity occurred in male or female animals except that 1 female exhibited ataxia during the first hour post-treatment. All of the males and females in the 1000 mg/kg group exhibited ataxia and 2 of the males also had tremors.