Registration Dossier
Registration Dossier
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EC number: 200-755-8 | CAS number: 71-48-7
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity
- Remarks:
- acute
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Abstract. Original reference not available.
Data source
Reference
- Reference Type:
- publication
- Title:
- Histofluorescence studies of monoamine neurons in the rat brain after cobaltous acetate intoxication.
- Author:
- Smialowska M, Bugera-Piekuch T, Bal A, Smialek M
- Year:
- 1 987
- Bibliographic source:
- Med Biol 65(4): 193-198
Materials and methods
- Principles of method if other than guideline:
- The aim was to study changes in brain monoamine neurons in an experimental animal model with an extrapyramidal motor syndrome of the parkinsonian type.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- - Name of test material (as cited in study report): cobaltous acetate
- Analytical purity: not reported
- Other: No information if anhydrate or tetrahydrate was used
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: no data
- Vehicle:
- not specified
Examinations
- Sacrifice and (histo)pathology:
- - Type of staining: histofluorescence and histological staining
Results and discussion
Any other information on results incl. tables
Neurological signs were observed in rats after acute cobaltous acetate intoxication under mild ischemic conditions. Histofluorescence studies showed a decrease in catecholamine fluorescence (which signifies a decrease in the amine content) in the hypothalamus and mesencephalic reticular formation, but not in the substantia nigra or basal ganglia. Serotonin fluorescence was increased in nerve cell bodies of the dorsal and median raphe nuclei and in nerve terminals in some thalamic and preoptic regions. Histological staining of sections adjacent to the fluorescent ones showed no neuronal loss and some pathology of myelin.
Applicant's summary and conclusion
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