Ethyl formate

Toxicity to aquatic algae and cyanobacteria

Link to relevant study record(s)

Reference

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Data is from computational model developed by USEPA

Justification for type of information:

Data is from computational model developed by USEPA

Qualifier:

according to guideline

Guideline:

other: Modeling database

Principles of method if other than guideline:

Estimation of 96 hr EC50 value of test chemical by modelling Database - ECOSAR v.1.11. The ECOSAR Class Program is a computerized version of the ECOSAR analysis procedures as currently practiced by the Office of Pollution Prevention and Toxics (OPPT).  It has been developed within the regulatory constraints of the Toxic Substances Control Act (TSCA).  It is a pragmatic approach to SAR. The structure-activity relationships (SARs) presented in this program are used to predict the aquatic toxicity of chemicals based on their similarity of structure to chemicals for which the aquatic toxicity has been previously measured.  Most SAR calculations in the ECOSAR Class Program are based upon the octanol/water partition coefficient (Kow).  Various surfactant SAR calculations are based upon the average length of carbon chains or the number of ethoxylate units.

GLP compliance:

not specified

Analytical monitoring:

not required

Vehicle:

not specified

Test organisms (species):

other: green algae

Test type:

static

Water media type:

freshwater

Total exposure duration:

96 h

Remarks on exposure duration:

Estimated data

Key result

Duration:

96 h

Dose descriptor:

EC50

Effect conc.:

131.702 mg/L

Nominal / measured:

estimated

Conc. based on:

test mat.

Basis for effect:

growth rate

Remarks on result:

other: Neutral Organics SAR (Baseline Toxicity)

Validity criteria fulfilled:

not specified

Conclusions:

The estimated EC50 values for aquatic green algae after 96 hours was 131 mg/l on the basis of growth rate.

Executive summary:

The short-term toxicity of the test substance Ethyl formate (CAS no.109 -94 -4) to green algae is predicted using EPI Suite ECOSAR version 1.10. On the basis of effects observed in a static freshwater system during a 96 hr exposure, the effect concentration (EC50) for the substance is estimated to be 131 mg/L. Based on this value, it can be concluded that the test chemical can be considered as non-toxic to green algae at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria.

 

Description of key information

The short-term toxicity of the test substanceEthyl formate (CAS no.109 -94 -4) to green algae is predicted using EPI Suite ECOSAR version 1.10 (2018). On the basis of effects observed in a static freshwater system during a 96 hr exposure, the effect concentration (EC50) for the substance is estimated to be 131 mg/L. Based on this value, it can be concluded that the test chemical can be considered as non-toxic to green algae at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria.

 

Key value for chemical safety assessment

EC50 for freshwater algae:

131 mg/L

Additional information

Predicted data for the test chemical Ethyl formate (CAS no.109 -94 -4) and various supporting weight of evidence studies for its read across chemical were reviewed for the toxicity to aquatic algae and cyanobacteria endpoint which are summarised as below:

In a prediction done using the EPI Suite ECOSAR version 1.10, the short-term toxicity of the test substance Ethyl formate (CAS no.109 -94 -4) to green algae is predicted using . On the basis of effects observed in a static freshwater system during a 96 hr exposure, the effect concentration (EC50) for the substance is estimated to be 131 mg/L.

In a supporting weight of evidence study, toxicity test for aquatic algae and cyanobacteria was performed using test material (Handbook, 2012). S. subspicatus was used for the test. It was tested for 72 h and 96h. The effect concentration for 72 h and 96 h was observed to be 240 mg/l and 190 mg/l respectively.

For the test chemical from authoritative database (2017), the test material was evaluated for its efficiency to cause toxicity on aquatic algae and cyanobacteria. Scenedesmus subspicatus (Green Algae) of exponential growth phase was evaluated in static condition for 48 h .The effect concentration was observed to be 5600 mg/l decrease in population was observed.

On the basis of the above results, it can be concluded that the test chemical can be considered as non-toxic to aquatic algae and thus can be considered to be not classified as per CLP classification criteria.