2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl)methylene]hydrazone

Endpoint summary

Description of key information

The Annex VIII of the REACH regulation requires an assessment of the toxicokinetic behaviour of the substance to the extent that can be derived from the relevant available information. There is no available data on the toxicokinetics of the chemical 2-hydroxynaphthalene-1-carbaldehyde [Synonym: C.I. Pigment Yellow 101].
Toxicokinetics is essentially the study of "how a substance gets into the body and what happens to it in the body". Four processes are involved in toxicokinetics; namely absorption, distribution, metabolism and excretion (ADME). It may be noted that the chemical 2-hydroxynaphthalene-1-carbaldehyde [Synonym: C.I. Pigment Yellow 101] is a fluorescent color having applications such as use in manufacturing of Daylight Fluorescent Resin Pigments, textile dyeing, ink application, plastic colouration, Leak / Crack Detection & Non-Destructive Testing (NDT).
Since the chemical is not a food dye, it is unlikely to be ingested and there is a low possibility of the chemical exerting a toxic effect after ingestion. The chemical is expected to have low potential for absorption across biological membranes due to the very low solubility in water and corresponding high estimated partition coefficient value. The particle size distribution of the chemical was found to be in the range of 150 micron to 25 micron. Thus, the likelihood of inhalation of these particles is low. 
Considering all of the above, this end point was considered for waiver. Also the bio-accumulation potential of the chemical is considered to be low.

Key value for chemical safety assessment

Bioaccumulation potential:

low bioaccumulation potential

Additional information

The Annex VIII of the REACH regulation requires an assessment of the toxicokinetic behaviour of the substance to the extent that can be derived from the relevant available information. There is no available data on the toxicokinetics of the chemical 2-hydroxynaphthalene-1-carbaldehyde [Synonym: C.I. Pigment Yellow 101]. Toxicokinetics is essentially the study of "how a substance gets into the body and what happens to it in the body". Four processes are involved in toxicokinetics; namely absorption, distribution, metabolism and excretion (ADME). It may be noted that the chemical 2-hydroxynaphthalene-1-carbaldehyde [Synonym: C.I. Pigment Yellow 101] is a fluorescent color having applications such as use in manufacturing of Daylight Fluorescent Resin Pigments, textile dyeing, ink application, plastic colouration, Leak / Crack Detection & Non-Destructive Testing (NDT). Since the chemical is not a food dye, it is unlikely to be ingested and there is a low possibility of the chemical exerting a toxic effect after ingestion. The chemical is expected to have low potential for absorption across biological membranes due to the very low solubility in water and corresponding high estimated partition coefficient value. The particle size distribution of the chemical was found to be in the range of 150 micron to 25 micron. Thus, the likelihood of inhalation of these particles is low. Considering all of the above, this end point was considered for waiver. Also the bio-accumulation potential of the chemical is considered to be low.