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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from BASF study report

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
14 days study investigated for determine the acute toxicity of the test substance Lumogen LT light yellow to rat by intraperitoneal route.
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl)methylene]hydrazone
EC Number:
219-210-0
EC Name:
2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl)methylene]hydrazone
Cas Number:
2387-03-3
Molecular formula:
C22H16N2O2
IUPAC Name:
1,1'-(hydrazine-1,2-diylidenedimethylylidene)di(2-naphthol)
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name of test material (as cited in study report):Lumogen LT light yellow- Molecular formula (if other than submission substance):C22H16N202- Molecular weight (if other than submission substance):340,385g/mol- Smiles notation (if other than submission substance):Oc1c(c2c(cccc2)cc1)\C=N\N=C\c1c2c(cccc2)ccc1O- InChl (if other than submission substance):1S/C22H16N2O2/c25-21-11-9-15-5-1-3-7-17(15)19(21)13-23-24-14-20-18-8-4-2-6-16(18)10-12-22(20)26/h1-14,25-26H/b23-13+,24-14+- Substance type:Organic- Physical state:Solid

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No details available

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
CMC (carboxymethyl cellulose)
Details on exposure:
VEHICLE- Concentration in vehicle: 15% suspention- Amount of vehicle (if gavage): 0.5% aqueous solution
Doses:
No data available
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days- Frequency of observations and weighing: No data- Necropsy of survivors performed:NO
Statistics:
No data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 3 100 mg/kg bw
Based on:
test mat.
Mortality:
No mortality was observed
Clinical signs:
Yellow colored feces observed
Body weight:
No data
Gross pathology:
No data

Applicant's summary and conclusion

Conclusions:
LD50 value for test substance Lumogen LT light yellow by intraperitoneal route was found to be >3100 mg/kg.
Executive summary:

During 14 days acute toxicity study 15% suspension of test substance Lumogen LT light yellow in 0.5% vehicle CMC (carboxymethyl cellulose) was given intraperitoneally to mouse.

LD50 value for test substance Lumogen LT light yellow by intraperitoneal route was found to be >3100mg/kg.

Based on the result of the experiment it is concluded that test substance Lumogen LT light yellow was non toxic by intraperitoneal route according to CLP criteria.