Registration Dossier

Diss Factsheets

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

The partition coefficient (log10 Pow) of the test item has been determined to be in the range 3.1 to 3.9 according to OECD Test Guideline 117. This is supported and in close agreement with the 2014 Givaudan supporting study which determined the partition coefficients (log10 Pow) to be in the range 3.0 to 3.8. The Harlan study was chosen as the key study as it gave the slightly higher and more conservative value.

Key value for chemical safety assessment

Log Kow (Log Pow):
3.9

Additional information

The partition coefficient of the test item was assessed using the HPLC method, designed to be compatible with Method A8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004 (Harlan 2015). The partition coefficient (log10 Pow) was determined to be in the range 3.1 to 3.9 with both of the main peaks 14.3% and 72.1% having a partition coefficient value of 3.9. 

This is supported by the 2014 Givaudan performed study determined by the Reverse Phase High Performance Liquid Chromatographic Method according to the OECD Guidelines for Testing of Chemicals, Method No. 117 which determined the Partition coefficients n-octanol/water of Pelargene: log10 Pow = 3.0; 3.4; 3.5; 3.6; 3.8 and 3.8; with both of the main peaks 16.2 and 74.8% having a partition coefficient value of 3.8. 

Testing was carried out at approximately neutral pH with the test item in a non-ionized form.

The chromatography of the test item showed six peaks with well-defined and reproducible retention times. The HPLC method was therefore considered to be suitable for the purpose of the test.

Categories Display