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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database.

Data source

Reference
Reference Type:
other: Authoritative database
Title:
Acute inhalation toxicity of test chemical
Author:
Jay A. Brown
Year:
2017
Bibliographic source:
Haz-Map: Information on Hazardous Chemicals and Occupational Diseases, 2017.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute inhalation toxicity study for the given test chemical in rats.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3,3'-(1,4-phenylenediimino)bis[4,5,6,7-tetrachloro-1H-isoindol-1-one]
EC Number:
226-999-5
EC Name:
3,3'-(1,4-phenylenediimino)bis[4,5,6,7-tetrachloro-1H-isoindol-1-one]
Cas Number:
5590-18-1
Molecular formula:
C22H6Cl8N4O2
IUPAC Name:
3,3'-(1,4-phenylenediimino)bis[4,5,6,7-tetrachloro-1H-isoindol-1-one]
Details on test material:
- IUPAC Name: 3,3'-(1,4-phenylenediimino)bis(4,5,6,7-tetrachloro-1H-isoindol-1-one)
- Common Name: C.I. Pigment Yellow 110
- InChI: 1S/C22H6Cl8N4O2/c23-11-7-9(13(25)17(29)15(11)27)21(35)33-19(7)31-5-1-2-6(4-3-5)32-20-8-10(22(36)34-20)14(26)18(30)16(28) 12(8)24/h1-4H,(H,31,33,35)(H,32,34,36)
- Smiles: C=1(c2c(c(c(Cl)c(Cl)c2C(=O)N1)Cl)Cl)Nc1ccc(cc1)NC1=NC(c2c1c(c(c(c2Cl)Cl)Cl)Cl)=O
- Molecular formula:C22H6Cl8N4O2
- Molecular weight:641.939 g/mole
- Substance type:Organic
- Physical state:Yellow odorless powder

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Remark on MMAD/GSD:
not specified
Details on inhalation exposure:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Remarks on duration:
not specified
Concentrations:
1000 mg/m3
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 1 000 mg/m³ air
Based on:
test mat.
Mortality:
No mortality was observed
Clinical signs:
other: not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The acute inhalation toxicity study in rat by using the test chemical was considered to be >1000 mg/m3.
Executive summary:

The acute inhalation toxicity study was conducted by using the given test chemical in rats at the concentration of 1000 mg/m3. No mortality was observed at 1000 mg/m3.

Therefore, the LC50 was considered to be >1000 mg/m3, when rats were treated with test chemical by inhalation.