Hexane-2,5-dione

Long-term toxicity to fish

Administrative data

Endpoint:

fish short-term toxicity test on embryo and sac-fry stages

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

2002

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Documentation insufficient for assessment

Data source

Reference

Reference Type:

publication

Title:

Entwicklung und Erprobung eines Teratogenitäts-Screening Testes mit Embryonen des Zebrabärblings Danio rerio

Author:

Jean Bachmann

Year:

2002

Bibliographic source:

Dissertation zur Erlangung des akademischen Grades Doctor rerum naturalium (Dr. rer. nat.) an der Fakultät für Forst-, Geo- und Hydrowissenschaften der Technischen Universität Dresden

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

other: Danio rerio Teratogenicity Assay

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Hexane-2,5-dione

EC Number:

203-738-3

EC Name:

Hexane-2,5-dione

Cas Number:

110-13-4

Molecular formula:

C6H10O2

IUPAC Name:

hexane-2,5-dione

Test material form:

not specified

Details on test material:

> 98 %, Sigma-Aldrich (Steinheim, Germany)

Sampling and analysis

Analytical monitoring:

not specified

Test solutions

Vehicle:

not specified

Test organisms

Test organisms (species):

Danio rerio (previous name: Brachydanio rerio)

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48

Remarks on exposure duration:

h

Post exposure observation period:

48 hours

Test conditions

Nominal and measured concentrations:

10,5; 15,8; 23,7; 35,5 and 53,2 mmol/L

Results and discussion

Effect concentrations

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

ca. 40 other: mmol/L