Registration Dossier
Registration Dossier
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EC number: 203-738-3 | CAS number: 110-13-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 940
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Test type:
- other:
- Limit test:
- no
Test material
- Reference substance name:
- Hexane-2,5-dione
- EC Number:
- 203-738-3
- EC Name:
- Hexane-2,5-dione
- Cas Number:
- 110-13-4
- Molecular formula:
- C6H10O2
- IUPAC Name:
- hexane-2,5-dione
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- other: mixed stock
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- 400-600 g
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- chamber temperature 25°C
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- > 10 - < 775 min
- Concentrations:
- saturated vapour, 0.04 % in air
- No. of animals per sex per dose:
- only one dose group (saturated vapour)
- Control animals:
- yes
- Details on study design:
- respiratory rate, pulse and rectal temperature were monitored at 10, 90, 145, 752 and 775 minutes
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- other: irritation, lacrimation
- Effect level:
- ca. 10 other: minutes
- Based on:
- other: saturated vapour
- Mortality:
- none
- Clinical signs:
- other: lacrimation, irritation, salivation, watery discharge from the nose
- Body weight:
- no data
- Gross pathology:
- not performed
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- At the conditions of the experiment no time-concentration-chart could be produced.
The only effect observed is irritation at all time points.
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