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Physical & Chemical properties

Water solubility

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Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 12 January 2016 to 10 February 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Principles of method if other than guideline:
Slow stir adaptation of the shake flask test method.
GLP compliance:
no
Remarks:
Non-GLP study performed by a GLP accredited lab.
Type of method:
flask method
Water solubility:
< 23 mg/L
Temp.:
25 °C
pH:
6.14
Remarks on result:
other: Mean results at day 1, 0.1% concentration
Water solubility:
31 mg/L
Temp.:
25 °C
pH:
5.3
Remarks on result:
other: Mean results at day 3, 0.1% concentration
Water solubility:
48 mg/L
Temp.:
25 °C
pH:
4.77
Remarks on result:
other: Mean results at day 7, 0.1% concentration
Water solubility:
44 mg/L
Temp.:
25 °C
pH:
5.18
Remarks on result:
other: Mean results at day 1, 0.5% concentration
Water solubility:
116 mg/L
Temp.:
25 °C
pH:
3.92
Remarks on result:
other: Mean results at day 3, 0.5% concentration
Water solubility:
162 mg/L
Temp.:
25 °C
pH:
3.68
Remarks on result:
other: Mean results at day 7, 0.5% concentration

Total concentration of the test substance for each replicate plus the average and reported concentrations

Test pH Total Concentration (mg/L) Average (mg/L) Reported Result (mg/L)
1 day, 0.1% 1 6.17 27.93 <22.6 <23
2 6.11 <17.20
3 day, 0.1% 1 5.23 32.59 30.9 31
2 5.37 29.31
7 day, 0.1% 1 5.04 39.48 47.8 48
2 4.50 56.21
1 day, 0.5% 1 5.69 33.28 43.5 44
2 4.68 53.79
    
3 day, 0.5%		 1 3.86 134.31 116.3 116
2 3.97 98.28
7 day, 0.5% 1 3.67 168.28 162.1 162
2 3.69 155.86
Water Blank 6.58 Not Detected Not Applicable Not Applicable
Conclusions:
Due to the variation observed during this study, it was not possible to derive a definitive value for the water solubility of the registered substance.
Executive summary:

When tested according to OECD Guideline 105, it was not possible to derive a definitive value for the water solubility of the registered substance. The water solubility will depend of the loading and of the duration of the study. The values ranged from <23 mg/L (day 1, 0.1 % concentration) to 162 mg/L (day 7, 0.5 % concentration) at 25 °C.

Description of key information

The study was performed on the registered substance. Depending on the test conditions, the water solubility ranged from <23 mg/L (day 1, 0.1 % concentration) to 162 mg/L (day 7, 0.5 % concentration) at 25 °C.

Key value for chemical safety assessment

Additional information

The water solubility of the registered substance was determined in accordance with the OECD Guideline for Testing of Chemicals 105. The results showed signs of loading and time dependency, and it was not possible to obtain a definitive value regarding the water solubility, which ranged from <23 mg/L (day 1, 0.1 % concentration) to 162 mg/L (day 7, 0.5 % concentration) at 25 °C - and therefore from slightly to moderately soluble - depending on the test conditions.