Registration Dossier
Registration Dossier
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EC number: 246-140-8 | CAS number: 24304-00-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1993
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The acute oral toxicity study of Gilbert (1993) was cited in the GLP 28 day repeated dose toxicity study (see section 7.5.2). This acute oral toxicity study was as a pre-test for the 28 day repeated dose toxicity study in the line of expecting toxicity responses and was conducted in the same laboratory (Toxicology Research Laboratory) as the 28 day repeated dose toxicity study. Therefore, the results are considered reliable even though the study is not reported in detail.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No detailed information was provided regarding the guideline followed.
- GLP compliance:
- not specified
- Test type:
- other: acute oral toxicity in rat
Test material
- Reference substance name:
- Aluminium nitride
- EC Number:
- 246-140-8
- EC Name:
- Aluminium nitride
- Cas Number:
- 24304-00-5
- Molecular formula:
- AlN
- IUPAC Name:
- alumanylidyneamine
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): Aluminum nitride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no further information available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- no further information available
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 3 males
- Control animals:
- not specified
- Details on study design:
- N.A.
- Statistics:
- N.A.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD0
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: three of three male rats survived doses of 2000 mg/kg bw
- Mortality:
- No mortality after treatment with 2000 mg/kg bw
- Clinical signs:
- other: no information provided
- Gross pathology:
- no information provided
- Other findings:
- no information provided
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The single dose oral toxicity of aluminium nitride is low as three of three male rats survived doses of 2000 mg/kg bw. The oral LD50 can be considered to be greater than 2000 mg/kg bw.
- Executive summary:
In an acute oral toxicity study, 3 male rats (no data on strain) were exposed to 2000 mg/kg aluminium nitride (Gilbert, 1993). The study was cited as a pre-test for a subsequent GLP 28-day repeated dose toxicity study (see section 7.5.2). Therefore, the results are considered reliable even though the study is not reported in detail.
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