Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
skin irritation / corrosion, other
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a (Q)SAR model, with limited documentation / justification
Justification for type of information:
QSAR prediction

Data source

Reference
Reference Type:
other: Predicted data
Title:
Unnamed
Year:
2015

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: REACH guidance on QSARs R.6, May/July2008
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(1H-indol-3yl)ethanamine
EC Number:
692-120-0
Cas Number:
124955-50-6
Molecular formula:
C10H12N2*H3PO4
IUPAC Name:
2-(1H-indol-3yl)ethanamine
Test material form:
solid: crystalline
Details on test material:
Test item: tryptamine phosphateCAS No.:124955-50-6Batch No.: S62233NPhysical state: brown or beige crystalline powderStorage: 8-15 °C, protected from light and wet

Results and discussion

In vivo

Results
Remarks on result:
no indication of irritation
Remarks:
(based on QSAR/QSPR prediction)

Any other information on results incl. tables

Software Method Alert Predicted value
ChemProp Skin irritation and corrosion No Structural Alerts were found. Save (Not irritating)
Toxtree Skin irritation / skin corrosion Physical properties Not Irritating or Corrosive to skin

Applicant's summary and conclusion

Interpretation of results:
not irritating
Conclusions:
According to (Q)SAR modell: Toxtree, ChemProp, the predicted values indicated that tryptamine phosphate is not irritating.