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EC number: 308-208-6 | CAS number: 97925-95-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- According to "Standard Operating Procedure No CT20-090/01" as cited in text, number of animals, analytical purity of test substance and experimental conditions not specified
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Ethanol, 2,2'-iminobis-, N-(C13-15-branched and linear alkyl) derivs.
- EC Number:
- 308-208-6
- EC Name:
- Ethanol, 2,2'-iminobis-, N-(C13-15-branched and linear alkyl) derivs.
- Cas Number:
- 97925-95-6
- Molecular formula:
- Not applicable - multiconstituent substance
- IUPAC Name:
- Ethanol, 2,2'-iminobis-, N-(C13-15-branched and linear alkyl) derivs.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Alderley Park, SPF-derived, albino strain
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: Young adult, not further specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: Material used as a 20% (w/v) emulsion in corn oil for a dose of 2000 mg/kg bw and as a 15%, 13.5%, 12.5% 10% and 5% (w/v) emulsion in corn oil for doses of 1500, 1350, 1250, 1000 and 500 mg/kg bw respectively. - Doses:
- 500, 1000, 1250, 1350, 1500 and 2000 mg/kg bw
- No. of animals per sex per dose:
- No data, but results of mortalities indicate that ≥5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: Up to 8 days reported
- Other examinations performed: clinical signs - Statistics:
- The LD50 was calculated by the logit method (Berkson, 1944)
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 500 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 100 - 2 000
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 300 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 250 - 2 000
- Mortality:
- 2000 mg/kg bw: 4 male and 5 female dead by day 6
1500 mg/kg bw: 2 male and 4 female dead by day 8
1350 mg/kg bw: Only females treated, all dead by day 4
1250 mg/kg bw: Only females treated, no deaths
1000 mg/kg bw: 1 male dead by day 4
500 mg/kg bw: No deaths - Clinical signs:
- other: 2000 mg/kg bw: Subdued appearance, piloerection, chromodacryorrhoea, scouring, curvature of spine, laboured respiration and a red stain around the snout 1500 mg/kg bw: Slight piloerection, incontinence, salivation and an ungroomed appearance 1350, 1250, 1
- Gross pathology:
- No data
Any other information on results incl. tables
Clinical signs observed in this study are reported to be indicative of excessive para-sympathetic nervous activity. Atmer 163 with a LD50 of 1500 mg/kg bw in male and 1300 mg/kg bw in female rats by oral route has to be classified:
CLP: Category 4, H302 (harmful if swallowed)
DSD: Xn, R22 (harmful)
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
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