Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012
Report date:
2013

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
4-hydroxybenzophenone
EC Number:
214-507-1
EC Name:
4-hydroxybenzophenone
Cas Number:
1137-42-4
Molecular formula:
C13H10O2
IUPAC Name:
4-benzoylphenol
Test material form:
solid: crystalline
Details on test material:
Name of test material (as cited in study report): 4-Hydroxybenzophenone
Analytical purity: 99.3 g/100g by 1H-NMR spectroscopy using the internal
standard method (determined during the GLP-study No.
11L00531 from Competence Center Analytics, BASF SE)

Results and discussion

Water solubility
Key result
Water solubility:
145 mg/L
Temp.:
20 °C
pH:
>= 6.2 - <= 6.3

Any other information on results incl. tables

Individual Results

Sample

mtest item

[g]

vwater

[ml]

pH

ctest item

singlevalues

[mg/l]

ctest item

mean

[mg/l]

Water used

5.9

 

 

1 / 24 h

85.49

100

6.2

145.90

147.26

146.58

2 / 48 h

86.92

100

6.3

148.44

149.63

149.04

3 / 72 h

86.73

100

6.3

140.78

140.90

140.84

Mean of allsingle values ± std. dev.

145.49 mg/l ± 3.81 mg/l

The water solubility of the test item is 145 ± 4 mg/l at T = 20.0 °C ± 0.5 °C, pH 6.3.

Applicant's summary and conclusion