N,N,N-trimethylanilinium chloride

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

experimental data of read across substances

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

WoE report is based on two hydrolysis studies as-
1., 2. and 3.

GLP compliance:

not specified

Radiolabelling:

not specified

Analytical monitoring:

not specified

Estimation method (if used):

1. No data available
2. Structure estimation method
3. No data available

Temp.:

55 °C

Remarks:

1. The study was performed at pH range 5-9, respectively.

Remarks:

2. The study was performed at pH 7 and 8, respectively.

Remarks:

3. Details not known

Positive controls:

not specified

Negative controls:

not specified

Transformation products:

not specified

Temp.:

55 °C

DT50:

> 29 - < 146 d

Remarks on result:

other: 1. The study was performed at pH range 5-9, respectively.

pH:

7

DT50:

5 yr

Type:

second order

Remarks on result:

other: 2. Hydrolysis rate constant of test chemical was determined to be 0.04 L/mol-sec

pH:

8

DT50:

200 d

Type:

second order

Remarks on result:

other: 2. Hydrolysis rate constant of test chemical was determined to be 0.04 L/mol-sec

pH:

7

Temp.:

25 °C

Hydrolysis rate constant:

0 s-1

DT50:

38 d

Type:

(pseudo-)first order (= half-life)

Remarks on result:

other: 3. Other details not known

Validity criteria fulfilled:

not specified

Conclusions:

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 29 days to 5 yrs, at pH range 5-9, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.

Executive summary:

Data available for the test chemical has been reviewed to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:

The half-life value of test chemical was determined at a pH range 5-9 and at a temperature of 55°C, respectively. The estimated half-life value of test chemical was determined to be ranges from 29 to 146 days, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

In an another study, the base catalyzed second order hydrolysis rate constant and half-life value of test chemical was determined using a structure estimation method. The second order hydrolysis rate constant was determined to be 0.04 L/mol-sec with a corresponding half-life of 5 years and 200 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

For the test chemical, the half-life of the test chemical was determined using an estimated pseudo-first order hydrolysis rate constant of 0.00000021/sec.The half-life of test chemical was determined to be 38 days at pH 7 and a temperature of 25°C, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 29 days to 5 yrs, at pH range 5-9, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.

Description of key information

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 29 days to 5 yrs, at pH range 5-9, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.

Additional information

Data available for the test chemical has been reviewed to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:

 

The half-life value of test chemical was determined at a pH range 5-9 and at a temperature of 55°C, respectively. The estimated half-life value of test chemical was determined to be ranges from 29 to 146 days, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

 

In an another study, the base catalyzed second order hydrolysis rate constant and half-life value of test chemical was determined using a structure estimation method. The second order hydrolysis rate constant was determined to be 0.04 L/mol-sec with a corresponding half-life of 5 years and 200 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

 

For the test chemical, the half-life of the test chemical was determined using an estimated pseudo-first order hydrolysis rate constant of 0.00000021/sec. The half-life of test chemical was determined to be 38 days at pH 7 and a temperature of 25°C, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

 

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 29 days to 5 yrs, at pH range 5-9, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.