Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

KEY STUDY, OECD 401 (KEY_401_1986_HOECHST_86.0391): LD50 female rat = 1930 mg/kg bw (= most sensitive sex)
NON-KEY STUDY, unspecified guideline (NONKEY-401-2007-MSDS SYNTHESIA): LD50 rat = 1105 mg/kg bw

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
1 930 mg/kg bw

Additional information

Testing for acute oral toxicity following OECD standard method revealed LD50 values of 2280 mg/kg bw for male and 1930 mg/kg bw for female rats. The lower value of 1930 mg/kg bw representing the most senitive response was identified to be suitable for classification purpose. Findings of a second supportive study (LD50: 1105 mg/kg bw) only available from a SDS, are not inconsistent with this conclusion.

Justification for classification or non-classification

The derived LD50 value of 1930 mg/kg bw meets criteria for classification as Xn, R 22 or Acute toxicity — Oral, Cat 4, H302.