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EC number: 210-412-4
CAS number: 615-16-7
test item 2-Benzimidazolol was assessed for its potential to induce gene
plate incorporation test (experiment I) and the pre-incubation test
(experiment II) usingSalmonella
typhimurium strains TA 1535, TA 1537, TA 98, and TA 100, and the Escherichia
coli strain WP2 uvrA.
assay was performed in two independent experiments both with and without
activation. Each concentration and the controls were tested in
item was tested at the following concentrations of the active ingredient:
10; 33; 100; 333; 1000; 2500; and 5000 µg/plate
100; 333; 1000; 2500; and 5000 µg/plate
plates incubated with the test item showed normal background growth up
pg/plate with and without S9 mix in both experiments.
toxic effects, evident as a reduction in the number of revertants (below
the indication factor of 0.5), occurred in the test groups with and
without metabolic activation.
substantial increase in revertant colony numbers of any of the five
tester strains wasobserved
following treatment with 2-Benzimidazolol at any dose level, neither in
nor absence of metabolic activation (S9 mix). There was also no tendency
of higher mutation rates with increasing concentrations in the range
below the generallyacknowledged
border of biological relevance.
reference mutagens were used as positive controls. They showed a
of induced revertant colonies.
conclusion, it can be stated that during the described mutagenicity test
and under the experimental
conditions reported, the test item did not induce gene mutations by base
or frameshifts in the genome of the strains used.
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