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EC number: 203-166-4 | CAS number: 104-01-8
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic / sediment:
From predicted model BCFBAF Program (v3.00) by EPI SUITE;2017 the estimated bio concentration factor (BCF) for 4-methoxyphenylacetic acid is 3.162 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000.Thus it is concluded that 4-methoxyphenylacetic acid is not expected to bio accumulate in the food chain.
Additional information
Bioaccumulation: aquatic / sediment:
By applying weight of evidence approach Experimental and Predicted data of Bioaccumulation endpoint for the target chemical (4-methoxyphenyl) acetic acid (Cas no. 104-01-8) and its read across chemical were reviewed to summarize as follows:
Study 1:
From prediction model BCFBAF Program (v3.00) by EPI SUITE;2017 the estimated bio concentration factor (BCF) for 4-methoxyphenylacetic acid is 3.162 L/kg wet-wt at 25 deg.C for target 4-methoxyphenylacetic acid.
Study 2:
Similarly other prediction model PBT profiler; 2017 indicate that the Bioaccumulation factor (BCF) was predicted to be 3.2 L/kg wet-wt at 25 deg.C for 4-methoxyphenylacetic acid.
Study 3:
Another predicted database i.e Scifinder; 2017 for target substance indicated the Bioconcentration factor (BCF) for target chemical 4-methoxyphenylacetic acid was predicted to be 5.10 at pH 1,5.09 at pH 2,4.93 at pH3, 3.76 at pH 4, 1.12 at pH 5, 1.0 at pH 6-10 and temperature 25 deg.C.
Study 4:
And Chemspider - ACD/PhysChem Suite predicted model the Bioconcentration factor (BCF) for target chemical 4-methoxyphenylacetic acid was predicted to be 1.00 at pH 5.5 and 7.4 at temperature 25 deg.C.
All 4 studies of target chemical based predicted models it is concluded that the test chemical 4-methoxyphenylacetic acid is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.
Study 5:
And from HSDB database; 2017 the read across chemical 4-chlorophenoxyacetic acid (Cas no. 122-88-3) indicate an estimated BCF of 3 was calculated for 4-chlorophenoxyacetic acid, using a log Kow of 2.25 and a regression derived equation. This BCF suggests the potential for bioconcentration in aquatic organisms is low.
Study 5 also support to predicted studies for target chemical.
Thus based on the above all studies it is concluded that the test substance chemical 4-methoxyphenylacetic acid (Cas no. 104-01-8) is non Bioaccumulative in aquatic environment.
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