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EC number: 412-570-1 | CAS number: 119462-56-5 PERKALINK 900
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 1992 - January 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- column elution method
- Key result
- Water solubility:
- 40.8 mg/L
- Temp.:
- 20 °C
- pH:
- >= 5.61 - <= 5.92
- Conclusions:
- Interpretation of results: slightly soluble (0.1-100 mg/L)
The water solubility of 1,3-bis(3-methyl-2,5-dioxo-1H-pyrrolinylmethyl)benzene was determined at 40.8 mg/L at 20 °C. - Executive summary:
The water solubility of 1,3-bis(3-methyl-2,5-dioxo-1H-pyrrolinylmethyl)benzene was determined to according to OECD method 105, EU method A.6. With the Flask shaking/column elution method the solubility was determined at 40.8 mg/L at 20 °C.
Wheaton vials containing 50 mg of 1,3-bis(3-methyl-2,5-dioxo-1H-pyrrolinylmethyl)benzene and 50 mL of distilled water were purged with nitrogen, sealed and shaken at 30 °C for 1, 2 and 3 days. On each occasion one vial was transferred to equilibrate at 20 °C for 24 hours. The samples were then filtered through 0.2 µ PTFE filters and the concentration of 1,3-bis(3-methyl-2,5-dioxo-1H-pyrrolinylmethyl)benzene determined by HPLC employing UV detection.
Reference
Measurements of water solubility at 20 °C
| Time (days) | |||||
| held | equilibrated | Concentration | Mean Concentration | pH | |
| at 30 °C | at 20 °C | (mg/L) | (mg/L) | ||
| 1 | 1 | 43.4 |
43.4 |
43.4 | 5.61 |
| 2 | 1 | 37.8 | 38.2 | 38.0 | 5.62 |
| 3 | 1 | 40.9 | 40.9 | 40.9 | 5.92 |
| Mean = 40.8 ± 2.4 mg/L | |||||
Description of key information
The water solubility of 1,3-bis(3-methyl-2,5-dioxo-1H-pyrrolinylmethyl)benzene was determined
to be 40.8 mg/L at 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 40.8 mg/L
- at the temperature of:
- 20 °C
Additional information
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