Registration Dossier

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Short-term toxicity to fish

Using the EPI Suite ECOSAR version 1.11, the short term toxicity on fish was predicted for Butane-1,2,3,4-tetracarboxylic acid (CAS no. 1703-58-8) the effects observed in a static freshwater system. The lethal concentration LC50 value for the Butane-1,2,3,4-tetracarboxylic acid was estimated to be 2220000 mg/l for fish for 96 hr exposure duration.

Short-term toxicity to aquatic invertebrates

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the six closest read across substances, the short term toxicity on aquatic invertebrates was predicted for Butane-1,2,3,4-tetracarboxylic acid (Cas no.1703-58-8). Effect concentration i.e EC50 value was estimated to be 445.8 mg/l for Daphnia magna for 48 hrs duration.

Toxicity to aquatic algae and cyanobacteria

Using QSAR Toolbox version 3.3 with log kow as the primary discriptors the EC50 value of Desmodesmus subspicatus for Butane-1,2,3,4-tetracarboxylic acid is estimated to be 173.17 mg/L.

Additional information

Short-term toxicity to fish

Three studies including predicted data from validated tools and authorative database for short term fish endpoint of test chemicalButane-1,2,3,4-tetracarboxylic acid(Cas no. 1703-58-8) were summarised as follows:

 

Using the EPI Suite ECOSAR version 1.11, the short term toxicity on fish was predicted for Butane-1,2,3,4-tetracarboxylic acid (CAS no. 1703-58-8) the effects observed in a static freshwater system. The lethal concentration LC50 value for the Butane-1,2,3,4-tetracarboxylic acid was estimated to be 2220000 mg/l for fish for 96 hr exposure duration.

 

Similar prediction by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program suggest the LC50 value for short term toxicity to aquatic invertebrates was predicted. On the basis of EPI suite, ECOSAR version 1.1, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be2740000mg/l for Butane-1,2,3,4-tetracarboxylic acid in 96 hrs.

 

One another result from authorative database i.e DANISH EPA indicate short term toxicity to fish Using Battery algorithm model of Danish QSAR Short-term toxicity toFathead minnowforButane-1,2,3,4-tetracarboxylic acid estimated to be LC50 is 5575.591 mg/L at 96 hrs.

 

Thus based on the all available effect concentrations which is in the range of 5575.591 mg/l to

2740000mg/l for target and read across chemicals which come to the conclusion that test substance Butane-1,2,3,4-tetracarboxylic acid (Cas no. 1703-58-8) was likely to be non-toxic to aquatic invertebrates as it not exceed the classification criteria, hence it can be considered to be not classified as per the CLP regulation.

Short-term toxicity to aquatic invertebrates

Four studies including predicted data from validated tools and experimental data from peer reviewedjournal and authorative database for short term aquatic invertebrate’s endpoint of test chemicalButane-1,2,3,4-tetracarboxylic acid(Cas no. 1703-58-8) with relevant read across which is close to target using log Kow as primary descriptor were summarised as follows:

 

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the six closest read across substances, the short term toxicity on aquatic invertebrates was predicted for Butane-1,2,3,4-tetracarboxylic acid (Cas no.1703-58-8). Effect concentration i.e EC50 value was estimated to be 445.8 mg/l for Daphnia magna for 48 hrs duration.

 

Similar prediction byUsing the EPI Suite ECOSAR version 1.11, the short term toxicity on fish was predicted for Butane-1,2,3,4-tetracarboxylic acid (CAS no. 1703-58-8) the effects observed in a freshwater system. The lethal concentration LC50 value for Butane-1,2,3,4-tetracarboxylic acid estimated to be 20500000 mg/l for fish for 96 hr exposure duration.

 

 

Above predicted results of target assist by experimental result of read across chemicalL-(+)-lactic acid(Cas no:79-33-4) from peer reviewed journalChemosphere 1998, In a 48-h short term toxicity test, 5 Daphnia magna were exposed to L-(+)-lactic acid at nominal concentrations of 0 (control), 320 and 560 mg/L under static conditions. The Effective concentration to 50% of Daphnia magna is 240 mg/l at which the organisms were immobile.

 

One another read across (Malonic acid)(Cas no.141-82-2) fromJournal of the Water Pollution Control Federation,1980. The effective concentration EC50 value forDaphnia magna when exposed to Malonic acid for 48 Hour is275 mg/l. on the basis of obtained value it can be concluded that the Malonic acid is not toxic toDaphnia magna.

 

Thus based on the all available effect concentrations which is in the range of240mg/l to20500000mg/l for target and read across chemicals which come to the conclusion that test substance Butane-1,2,3,4-tetracarboxylic acid (Cas no. 1703-58-8) was likely to be non-toxic to aquatic algae as it not exceed the classification criteria, hence it can be considered to be not classified as per the CLP regulation.

Toxicity to aquatic algae and cyanobacteria

Five studies including predicted data from validated tools and experimental data fromfor toxicity to aquatic algae endpoint of test chemicalButane-1,2,3,4-tetracarboxylic acid(Cas no.1703-58-8) with relevant read across which is close to target using log Kow as primary descriptor were

summarised as follows:

 

Using QSAR Toolbox version 3.3 with log kow as the primary discriptors the EC50 value of Desmodesmus subspicatus for Butane-1,2,3,4-tetracarboxylic acid is estimated to be 173.17 mg/L.

Based on the estimated results, Butane-1,2,3,4-tetracarboxylic acid can be concluded not to aquatic algae and can be classified under the categoryNot Classifiedas per CLP regulation

 

Similar prediction by EPI suite, ECOSAR version 1.1the 96 hours EC50 was estimated to be 187000 mg/l on algae for Butane-1,2,3,4-tetracarboxylic acid with growth inhibition effects.

 

 

Another prediction Using Battery algorithm model of Danish QSAR Short-term toxicity to Pseudokirchneriella subcapitata for Butane-1,2,3,4-tetracarboxylic acid estimated to be EC50 1269.002 mg/L at 72 hrs.

 

Above predicted results of target assist by experimental result of read across chemicalEdetic acid(Cas no:60-00-4) from peer reviewed journalArchives of Environmental Contamination and Toxicology 2009, In Toxicity to aquatic algae test Isochrysis galbana exposed to Edetic acid for 5 mins duration to study the effects, since no observable effects at a concentration were observed. No observable effect concentration (NOEC) for Isochrysis galbana is 240 mg/L at 5 mins.

 

One another read across (1,2,3-Propanetricarboxylic acid, 2-hydroxy-, hydrate (1:1)(Cas no.5949-29-1) fromDeutsche gewässerkundliche Mitteilungen,1991 Toxicity test on algae for 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, hydrate (1:1) was carried out to study the Physiology (Assimilation efficiency) effects of Chlorococcales when it is exposed for 24 hrs under static condition.

Effective concentration to 10% of Chlorococcales is 1000 mg/L at 24 hrs at which Physiology (Assimilation efficiency) effects were measured. No significant effects were observed..

 

Thus based on the all available effect concentrations which is in the range of173.17mg/l to187000mg/l for target and read across chemicals which come to the conclusion that test substance Butane-1,2,3,4-tetracarboxylic acid (Cas no. 1703-58-8) was likely to be non-toxic to aquatic algae as it not exceed the classification criteria, hence it can be considered to be not classified as per the CLP regulation.

Categories Display