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Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from prediction model by US EPA
Qualifier:
according to guideline
Guideline:
other: modelling database
Principles of method if other than guideline:
ECOSAR v1.00
GLP compliance:
no
Specific details on test material used for the study:
Name of test material: Butane-1,2,3,4-tetracarboxylic acid-Molecular formula: C8H10O8-Molecular weight: 234.160 g/mol-Smiles notation : C(C(C(CC(=O)O)C(=O)O)C(=O)O)C(=O)O- InChl (if other than submission substance): InChI=1S/C8H10O8/c9-5(10)1-3(7(13)14)4(8(15)16)2-6(11)12/h3-4H,1-2H2,(H,9,10)(H,11,12)(H,13,14)(H,15,16)- Substance type: Organic-Physical Appearance: Solid
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
other: fish
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Test temperature:
25 Deg.C
Key result
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
2 220 000 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Conclusions:
Based on the EPI Suite ECOSAR version 1.10 prediction model, the 96 hours LC50 was estimated to be 2220000 mg/l on Fish for Butane-1,2,3,4-tetracarboxylic acid (CAS no. 1703-58-8) on the basis of mortality effects. .
Executive summary:

Using the EPI Suite ECOSAR version 1.11, the short term toxicity on fish was predicted for Butane-1,2,3,4-tetracarboxylic acid (CAS no. 1703-58-8) the effects observed in a static freshwater system. The lethal concentration LC50 value for the Butane-1,2,3,4-tetracarboxylic acid was estimated to be 2220000 mg/l for fish for 96 hr exposure duration. Based on this lethal value it can be concluded that the Butane-1,2,3,4-tetracarboxylic acid (CAS no. 1703-58-8) can be considered to be non toxic to aquatic environment and thus it become not classified as per the CLP classification criteria.

Description of key information

Using the EPI Suite ECOSAR version 1.11, the short term toxicity on fish was predicted for Butane-1,2,3,4-tetracarboxylic acid (CAS no. 1703-58-8) the effects observed in a static freshwater system. The lethal concentration LC50 value for the Butane-1,2,3,4-tetracarboxylic acid was estimated to be 2220000 mg/l for fish for 96 hr exposure duration. Based on this lethal value it can be concluded that the Butane-1,2,3,4-tetracarboxylic acid (CAS no. 1703-58-8) can be considered to be non toxic to aquatic environment and thus it become not classified as per the CLP classification criteria.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
2 220 000 mg/L

Additional information

Three studies including predicted data from validated tools and authorative database for short term fish endpoint of test chemical Butane-1,2,3,4-tetracarboxylic acid(Cas no. 1703-58-8) were summarised as follows:

 

Using the EPI Suite ECOSAR version 1.11, the short term toxicity on fish was predicted for Butane-1,2,3,4-tetracarboxylic acid (CAS no. 1703-58-8) the effects observed in a static freshwater system. The lethal concentration LC50 value for the Butane-1,2,3,4-tetracarboxylic acid was estimated to be 2220000 mg/l for fish for 96 hr exposure duration.

 

Similar prediction by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program suggest the LC50 value for short term toxicity to aquatic invertebrates was predicted. On the basis of EPI suite, ECOSAR version 1.1, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be2740000mg/l for Butane-1,2,3,4-tetracarboxylic acid in 96 hrs.

 

One another result from authorative database i.e DANISH EPA indicate short term toxicity to fish Using Battery algorithm model of Danish QSAR Short-term toxicity toFathead minnowforButane-1,2,3,4-tetracarboxylic acid estimated to be LC50 is 5575.591 mg/L at 96 hrs.

 

Thus based on the all available effect concentrations which is in the range of 5575.591 mg/l to 2740000 mg/l for target and read across chemicals which come to the conclusion that test substance Butane-1,2,3,4-tetracarboxylic acid (Cas no. 1703-58-8) was likely to be non-toxic to aquatic invertebrates as it not exceed the classification criteria, hence it can be considered to be not classified as per the CLP regulation.

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