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EC number: 258-649-2
CAS number: 53585-53-8
Available information indicate that the Dibenzylbenzene, ar-methyl derivative is practically not toxic after single oral (LD50 > 10360 mg/kg), dermal (LD0 > 2000 mg/kg) or inhalative (LC0 > 0.24 mg/m³) exposure.
The acute oral toxicity of Dibenzylbenzene,
ar-methyl derivative was tested on male and female Sprague-dawley rats
at the limit dose of 10360 mg/kg. No mortality was observed during the
exposure and 14 days following the exposure. Piloerection was noted in
all the treated animals, 4.5 hours after the administration of
Dibenzylbenzene, ar-methyl derivative but was no more observed the
following day. No differences in body weight gain or in macroscopic
findings were observed.
Under these experimental conditions, the LD0
was consider to be > 10360 mg/kg.
inhalation toxicity of Dibenzylbenzene,
ar-methyl derivativewas evaluated in a
4-hour, single-exposure study in rats at the concentration of 0.24 mg/L,
according to a protocol study close to OECD Guideline 403 (May 12th1981)
with acceptable restrictions.
clinical observations for clinical signs and body weight changes were
evaluated over a 14-day observation period.All
animals were subjected to a gross necropsy.
was observed. During the exposure, initial agitation was first observed
before sedation occurred (10 minutes after the start of exposure). After
30 minutes, eyes were closed but reactivity to noise was normal.
Afterwards and until the end of the observation period, behaviours were
normal. No abnormalities were
observed at necropsy.
Table: Number of animals dead [and with
Mortality (# dead/total)
Time range of deaths (hours)
Number with evident toxicity (#/total)
The acute dermal toxicity of
Dibenzylbenzene, ar-methyl derivative was tested in male and female
Wistar rats at the limit dose of 2000 mg/kg. No mortality was observed
during the exposure and 14 days following the exposure. Under the
conditions of the study, the LD50 was considered to be > 2000 mg/kg.
The acute dermal toxicity of
Dibenzylbenzene, ar-methyl derivative was determined in rabbits in a
limit test (2000 mg/kg bw) performed according the French Guideline
AFNOR NF T03 -333. The mortality and general behavior of the animals
were observed for a period of 14 days after the administration of the
No mortality was observed at the dose-level
of 2000 mg/kg. The general behavior and the bodyweight of the animals
were not influenced by the treatment.
The dermal LD50 of the substance was found
to be greater than 2000 mg/kg bw; therefore, no classification for acute
dermal toxicity should be required.
The acute toxicity of Dibenzylbenzene,
ar-methyl derivative was evaluated in various studies, using oral and
dermal exposure, as well as exposure via inhalation. All data
demonstrate that Dibenzylbenzene, ar-methyl derivative is of low
toxicity after single administration. The LD50 values after oral and
dermal application are above 2000 mg/kg bw. No mortality was observed
after a single exposure of up to 15.6 mg/L for one hour.
No classification for acute toxicity is
indicated according to the general classification and labeling
requirements for dangerous substances and preparations (67/544 EEC) or
the classification, labeling and packaging (CLP) regulation (EC
However, hydrocarbons with viscosity below
20 mm²/s at 40 °C poses aspiration hazard.
CLP: Asp. Tox. 1
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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