Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

In accordance to section 2 of REACH Annex XI, skin and eye irritation studies do not need to be conducted as the substance is a gas. 

Key value for chemical safety assessment

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

The gaseous nature of 1,1,1,2,3,3,3 -heptafluoropropane precludes the conduct of conventional skin and eye irritation tests in animals.

No signs of respiratory tract irritation were observed in the available acute and repeated dose studies, indicating that the substance is not a respiratory tract irritant.

Effect level: empty Endpoint conclusion: Adverse effect observed

Justification for classification or non-classification

Based on the available negative eye irritation study and due to gaseous nature of the substance, classification of 1,1,1,2,3,3,3 -heptafluoropropane for skin and eye irritation is not applicable according to EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.