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EC number: 207-079-2 | CAS number: 431-89-0
The NOAEL for repeated dose toxicity is higher than 731690 mg/m3 (105000 ppm) in rats exposed for a period of 90 days.
In accordance with section 2 of REACH Annex XI, studies via the oral and dermal route do not need to be conducted as the substance is a gas.
Repeated administration of 1,1,1,2,3,3,3-heptafluoropropane (HFC 227ea) to rats by inhalation over 90 days (WIL Research Laboratories, 1993a) did not induce treatment-related effects at any dose tested (139370, 348420 and 731690 mg/m3 (20000, 50000 and 105000 ppm). All treated animals survived until termination. The NOAEC for systemic toxicity was established to be > 731690 mg/m3 (105000 ppm), 6 hr/day.
The NOAEC of 731690 mg/m3 observed in the subchronic inhalation toxicity study with rats will be used for DNEL derivation for repeated dose toxicity.
Based on the absence of any adverse effects in a subacute and semichronic toxicity study with rats, classification for repeated dose toxicity is not warranted according to EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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