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EC number: 236-112-3 | CAS number: 13170-23-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- A FDA study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
Materials and methods
- Principles of method if other than guideline:
- Following mating, adult female albino rats (Wistar) were dosed daily by oral intubation beginning on day 6 of gestation. Animals were observed daily and body weights recorded. On day 20, Caesarian sections were performed on all dams and the numbers of implantation sites, resorption sites, and live and dead fetuses was recorded. General external and internal examinations were also made of the dams.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Acetic acid
- EC Number:
- 200-580-7
- EC Name:
- Acetic acid
- Cas Number:
- 64-19-7
- Molecular formula:
- C2H4O2
- IUPAC Name:
- acetic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- Exposure period: 10 days (beginning on day 6 of gestation).
- Frequency of treatment:
- Daily
- Duration of test:
- 14 days
Doses / concentrationsopen allclose all
- Dose / conc.:
- 16 mg/kg bw/day (nominal)
- Dose / conc.:
- 74 mg/kg bw/day (nominal)
- Dose / conc.:
- 345 mg/kg bw/day (nominal)
- Dose / conc.:
- 1 600 mg/kg bw/day (nominal)
- No. of animals per sex per dose:
- Only female animals were used.
- Control animals:
- yes, concurrent no treatment
Examinations
- Maternal examinations:
- Animals were observed daily and body weights recorded.
- Ovaries and uterine content:
- On day 20, Caesarian sections were performed on all dams and the numbers of implantation sites and resorption sites was recorded.
- Fetal examinations:
- After cesarea, the numbers of live and dead fetuses was recorded.
General external and internal examinations were also made of the dams.
Results and discussion
Results: maternal animals
General toxicity (maternal animals)
- Clinical signs:
- not specified
- Dermal irritation (if dermal study):
- not specified
- Mortality:
- no mortality observed
- Description (incidence):
- No effects on maternal survival were observed at doses up to 1600 mg/kg bw/day.
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- no effects observed
Maternal developmental toxicity
- Number of abortions:
- no effects observed
- Description (incidence and severity):
- No effects on nidation were observed at doses up to 1600 mg/kg bw/day.
- Pre- and post-implantation loss:
- no effects observed
- Description (incidence and severity):
- No effects on nidation survival were observed at doses up to 1600 mg/kg bw/day.
- Total litter losses by resorption:
- not specified
- Early or late resorptions:
- not specified
- Dead fetuses:
- no effects observed
- Changes in pregnancy duration:
- not specified
- Description (incidence and severity):
- Migrated Data from removed field(s)
Field "Effects on pregnancy duration" (Path: ENDPOINT_STUDY_RECORD.DevelopmentalToxicityTeratogenicity.ResultsAndDiscussion.ResultsMaternalAnimals.MaternalDevelopmentalToxicity.EffectsOnPregnancyDuration): not specified - Changes in number of pregnant:
- not specified
- Other effects:
- no effects observed
Effect levels (maternal animals)
open allclose all
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- >= 1 600 mg/kg bw/day
- Based on:
- test mat.
- Basis for effect level:
- other: maternal toxicity
- Remarks on result:
- other: No adverse effect observed at the highest dose tested
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- >= 1 600 mg/kg bw/day
- Based on:
- test mat.
- Basis for effect level:
- other: developmental toxicity
- Remarks on result:
- other: No adverse effect observed at the highest dose tested
Maternal abnormalities
- Key result
- Abnormalities:
- no effects observed
Results (fetuses)
- Fetal body weight changes:
- not specified
- Description (incidence and severity):
- Migrated Data from removed field(s)
Field "Fetal/pup body weight changes" (Path: ENDPOINT_STUDY_RECORD.DevelopmentalToxicityTeratogenicity.ResultsAndDiscussion.ResultsFetuses.FetalPupBodyWeightChanges): not specified - Reduction in number of live offspring:
- no effects observed
- Description (incidence and severity):
- No effects on fetal survival were observed at doses up to 1600 mg/kg bw/day.
- Changes in sex ratio:
- not specified
- Changes in litter size and weights:
- not specified
- Changes in postnatal survival:
- no effects observed
- Description (incidence and severity):
- No effects on fetal survival were observed at doses up to 1600 mg/kg bw/day.
- External malformations:
- not specified
- Skeletal malformations:
- effects observed, non-treatment-related
- Description (incidence and severity):
- The number of abnormalities seen in skeletal tissues of the test groups did not differ from the number occurring in the controls.
- Visceral malformations:
- effects observed, non-treatment-related
- Description (incidence and severity):
- The number of abnormalities seen in soft tissues of the test groups did not differ from the number occurring in the controls.
- Other effects:
- no effects observed
Effect levels (fetuses)
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- >= 1 600 mg/kg bw/day
- Based on:
- test mat.
- Basis for effect level:
- other: fetuses toxicity
- Remarks on result:
- other: No adverse effect observed at the highest dose tested
Fetal abnormalities
- Key result
- Abnormalities:
- effects observed, non-treatment-related
- Localisation:
- other: soft and skeletal tissues
Overall developmental toxicity
- Key result
- Developmental effects observed:
- no
Any other information on results incl. tables
No effects on nidation or on maternal or fetal survival at doses up to 1600 mg/kg bw/day. The number of abnormalities seen in either soft or skeletal tissues of the test groups did not differ from the number occurring in the controls.
Applicant's summary and conclusion
- Conclusions:
- No effects on nidation or on maternal or fetal survival at doses up to 1600 mg/kg bw/day. The number of abnormalities seen in either soft or skeletal tissues of the test groups did not differ from the number occurring in the controls.
- Executive summary:
Following mating, adult female albino rats (Wistar) were dosed daily by oral intubation beginning on day 6 of gestation. Tested doses were 0, 16, 74, 345, and 1600 mg/kg bw/day. Animals were observed daily and body weights recorded. On day 20, Caesarian sections were performed on all dams and the numbers of implantation sites, resorption sites, and live and dead fetuses was recorded. General external and internal examinations were also made of the dams.
No effects on nidation or on maternal or fetal survival at doses up to 1600 mg/kg bw/day. The number of abnormalities seen in either soft or skeletal tissues of the test groups did not differ from the number occurring in the controls.
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