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Physical & Chemical properties

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
no data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient documentation for an assessment of reliability.
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2006
Report date:
2006

Materials and methods

Principles of method if other than guideline:
An excess of product is shaked with solvent during 24 hours at 20 deg C. After filtration the concentration in solution is determined with spectrometry.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
METHYL (1R,2R,4S)-2-[HEX-5-EN-1-YL(METHYL)CARBAMOYL]-4-({7-METHOXY-8-METHYL-2-[4-(PROPAN-2-YL)-1,3-THIAZOL-2-YL]QUINOLIN-4-YL}OXY)CYCLOPENTANECARBOXYLATE
EC Number:
922-147-8
Cas Number:
1042695-87-3
Molecular formula:
C32H41N3O5S
IUPAC Name:
METHYL (1R,2R,4S)-2-[HEX-5-EN-1-YL(METHYL)CARBAMOYL]-4-({7-METHOXY-8-METHYL-2-[4-(PROPAN-2-YL)-1,3-THIAZOL-2-YL]QUINOLIN-4-YL}OXY)CYCLOPENTANECARBOXYLATE
Test material form:
solid: particulate/powder
Details on test material:
- Name of test material (as cited in study reports): JNJ-39125593-AAA (T003019)
- Physical state: solid
- Appearance: white powder
Specific details on test material used for the study:
no data

Results and discussion

Solubility in organic solvents / fat solubilityopen allclose all
Medium:
methanol
Solubility:
32 g/L
Temp.:
20 °C
Medium:
ethanol
Solubility:
30 g/L
Temp.:
20 °C
Medium:
other: 2-propanol
Solubility:
13 g/L
Temp.:
20 °C
Medium:
other: dichloromethane
Solubility:
> 200 g/L
Temp.:
20 °C
Medium:
other: 2-propanone
Solubility:
> 200 g/L
Temp.:
20 °C
Medium:
ethyl acetate
Solubility:
130 g/L
Temp.:
20 °C
Medium:
other: methyl benzene
Solubility:
270 g/L
Temp.:
20 °C
Medium:
other: 4-methyl-2-pentanon
Solubility:
170 g/L
Temp.:
20 °C
Medium:
other: 2-butanone
Solubility:
> 200 g/L
Temp.:
20 °C
Medium:
other: 1-methoxy-2-propanol
Solubility:
110 g/L
Temp.:
20 °C
Details on results:
no data

Any other information on results incl. tables

Results on solubility in organic solvents:

 Solvent  Solubility in g/1L solution
N,N-dimethylacetamide   > 200
 N,N-dimethylformamide  > 200
 acetonitrile  46
 tetrahydrofurane  > 200
 acetic acid 180
 acetic acid/water (10/90, v/v) (pH = 2.2)  < 0.01
 1-butanol 31
 2-butanol 19
 heptane 0.76 
 2 -methyltetrahydrofurane > 200

Applicant's summary and conclusion