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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
16 February 2017 to 03 March 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
> 10
Temp.:
40 °C
pH:
7
Details on results:
RESULTS
- The estimated Log10 Pow for the representative structures of the test item were calculated to > 10.
- Typical chromatography for the definitive test is presented in Appendix 1 (attached).
- Retention times of the dead time and retention times, capacity factors (k’) and Log10 Pow values for the reference standards are shown in Table 19 (attached).
- The calibration curve from which the sample results were taken is shown in Figure 5 (attached).
- Retention times, capacity factor and Log10 Pow values determined for the sample are shown in Table 20 (attached).
Conclusions:
The partition coefficient of the test item was determined to be greater than 1.0 x 10E10 with a Log10 Pow of > 10.0.
Executive summary:

GUIDELINE

The determination was carried out using the HPLC method and a procedure designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.

 

RESULTS

The partition coefficient of the test item was determined to be greater than 1.0 x 10E10 with a Log10 Pow of > 10.0.

Description of key information

The partition coefficient of the test item was determined to be greater than 1.0 x 10E10 with a Log10 Pow of > 10.0 (OECD 117 and EU Method A.8).

Key value for chemical safety assessment

Additional information

GUIDELINE

The determination was carried out using the HPLC method and a procedure designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.

 

RESULTS

The partition coefficient of the test item was determined to be greater than 1.0 x 10E10 with a Log10 Pow of > 10.0.

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